Expression of CD83 in the murine immune system
- PMID: 12687354
- DOI: 10.1007/s00430-003-0179-9
Expression of CD83 in the murine immune system
Abstract
CD83 is used as a marker for mature dendritic cells (DC) in man. We have developed a new monoclonal antibody (mAb), Michel-17, that specifically recognizes mouse CD83. We show that murine CD83 is expressed mainly on mature DC and on activated T cells. Histological analysis of serial spleen sections revealed a CD83 expression pattern resembling that of MIDC-8, a known murine DC marker molecule. In contrast to other costimulatory receptors, cross-linking of CD83 with the mAb Michel-17 on DC or T cells does not induce any activation signals. Our data describe for the first time the expression pattern of murine CD83, which is comparable to that of human CD83. The unique mAb Michel-17 will help to elucidate the biological functions of the CD83 molecule in more detail.
Similar articles
-
CD83: an update on functions and prospects of the maturation marker of dendritic cells.Arch Dermatol Res. 2007 May;299(2):59-69. doi: 10.1007/s00403-007-0743-z. Epub 2007 Mar 4. Arch Dermatol Res. 2007. PMID: 17334966 Review.
-
CD83 expression on dendritic cells and T cells: correlation with effective immune responses.Eur J Immunol. 2007 Mar;37(3):686-95. doi: 10.1002/eji.200636535. Eur J Immunol. 2007. PMID: 17301951
-
Enhanced activation of CD83-positive T cells.Scand J Immunol. 2003 Sep;58(3):306-11. doi: 10.1046/j.1365-3083.2003.01303.x. Scand J Immunol. 2003. PMID: 12950676
-
Role of CD83 in the immunomodulation of dendritic cells.Int Arch Allergy Immunol. 2002 Oct;129(2):113-8. doi: 10.1159/000065883. Int Arch Allergy Immunol. 2002. PMID: 12403928 Review.
-
Activation-induced expression of murine CD83 on T cells and identification of a specific CD83 ligand on murine B cells.Int Immunol. 2000 Sep;12(9):1347-51. doi: 10.1093/intimm/12.9.1347. Int Immunol. 2000. PMID: 10967030
Cited by
-
Micro/Nanostructured Topography on Titanium Orchestrates Dendritic Cell Adhesion and Activation via β2 Integrin-FAK Signals.Int J Nanomedicine. 2022 Nov 1;17:5117-5136. doi: 10.2147/IJN.S381222. eCollection 2022. Int J Nanomedicine. 2022. PMID: 36345509 Free PMC article.
-
CD83 expression regulates antibody production in response to influenza A virus infection.Virol J. 2020 Dec 10;17(1):194. doi: 10.1186/s12985-020-01465-0. Virol J. 2020. PMID: 33302987 Free PMC article.
-
Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica.Vet Res. 2020 Mar 4;51(1):33. doi: 10.1186/s13567-020-00757-1. Vet Res. 2020. PMID: 32131896 Free PMC article.
-
Immunophenotyping of Sheep Paraffin-Embedded Peripheral Lymph Nodes.Front Immunol. 2018 Dec 11;9:2892. doi: 10.3389/fimmu.2018.02892. eCollection 2018. Front Immunol. 2018. PMID: 30619264 Free PMC article.
-
A Kinetic Study of CD83 Reveals an Upregulation and Higher Production of sCD83 in Lymphocytes from Pregnant Mice.Front Immunol. 2017 Apr 26;8:486. doi: 10.3389/fimmu.2017.00486. eCollection 2017. Front Immunol. 2017. PMID: 28491062 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous