Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls
- PMID: 12913707
- DOI: 10.1097/01.ju.0000082252.49374.e9
Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls
Abstract
Purpose: Chronic prostatitis has been traditionally characterized by inflammation and/or infection of the prostate gland, objectively categorized by white blood cells and cultured bacteria in prostate specific specimens. We compared leukocyte counts and localization rates for bacterial cultures of segmented urine samples (VB1, VB2, VB3), expressed prostatic secretion (EPS) and semen in men diagnosed with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) to men without pelvic pain (controls).
Materials and methods: A total of 463 men enrolled in the National Institutes of Health Chronic Prostatitis Cohort study and 121 age matched men without urinary symptoms had leukocyte counts performed and 5-day bacterial cultures on specimens obtained from a standard 4-glass test (VB1, VB2, EPS, VB3) and semen. All risk factor comparisons between case and control analyses were tested using generalized Mantel-Haenszel methods, and multivariable models were developed using logistic regression methods, adjusting for clustering by clinical center within both methods.
Results: Men with CP/CPPS had statistically higher leukocyte counts in all segmented urine samples and EPS, but not in semen compared to asymptomatic control men. However, the control population also had a high prevalence of leukocytes. Of the men with CP/CPPS 50% and 32% had 5 or more, or 10 or more white blood cells (WBCs) per high power field, respectively, in EPS compared to 40% and 20% of the control population. Similarly, 32% and 14% of the patients with CP/CPPS had 5 or more, or 10 or more WBCs per high power field in VB3 compared to 19% and 11% in the control population. Localization of uropathogenic bacteria in EPS, VB3 and/or semen was similar in men with CP/CPPS (8.0%) and asymptomatic men (8.3%).
Conclusions: Men with CP/CPPS have significantly higher leukocyte counts in all segmented urine samples and EPS but not in semen as compared to controls. There is no difference in rates of localization of bacterial cultures for men with CP/CPPS compared to control men. The high prevalence of WBCs and positive bacterial cultures in the asymptomatic control population raises questions about the clinical usefulness of the standard 4-glass test as a diagnostic tool in men with CP/CPPS.
Similar articles
-
How does the pre-massage and post-massage 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/chronic pelvic pain syndrome?J Urol. 2006 Jul;176(1):119-24. doi: 10.1016/S0022-5347(06)00498-8. J Urol. 2006. PMID: 16753385
-
Prostate-specific antigen test in diagnostic evaluation of chronic prostatitis/chronic pelvic pain syndrome.Urology. 2006 Feb;67(2):337-42. doi: 10.1016/j.urology.2005.08.031. Epub 2006 Jan 25. Urology. 2006. PMID: 16442595
-
IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis.J Urol. 2000 Jul;164(1):214-8. J Urol. 2000. PMID: 10840462
-
[Some controversial conditions in the management of chronic prostatitis/chronic pelvic pain syndrome].Zhonghua Nan Ke Xue. 2003 Sep;9(6):403-6. Zhonghua Nan Ke Xue. 2003. PMID: 14574800 Review. Chinese.
-
Acute and chronic prostatitis.Med Clin North Am. 2004 Mar;88(2):483-94. doi: 10.1016/S0025-7125(03)00169-X. Med Clin North Am. 2004. PMID: 15049589 Review.
Cited by
-
Impaired Semen Quality in Patients with Chronic Prostatitis.J Clin Med. 2024 May 14;13(10):2884. doi: 10.3390/jcm13102884. J Clin Med. 2024. PMID: 38792425 Free PMC article.
-
Case report: Successful treatment of recurrent E. coli infection with bacteriophage therapy for patient suffering from chronic bacterial prostatitis.Front Pharmacol. 2023 Sep 18;14:1243824. doi: 10.3389/fphar.2023.1243824. eCollection 2023. Front Pharmacol. 2023. PMID: 37790805 Free PMC article.
-
Chronic Pelvic Pain: A Comprehensive Review.Cureus. 2022 Oct 26;14(10):e30691. doi: 10.7759/cureus.30691. eCollection 2022 Oct. Cureus. 2022. PMID: 36465795 Free PMC article. Review.
-
Neuroinflammatory gene expression in chronic prostatitis/chronic pelvic pain syndrome patients: insights into etiology and phenotype biology.Transl Androl Urol. 2021 Aug;10(8):3340-3347. doi: 10.21037/tau-21-387. Transl Androl Urol. 2021. PMID: 34532258 Free PMC article.
-
Chronic Prostatitis and Pelvic Pain Syndrome: Another Autoimmune Disease?Arch Immunol Ther Exp (Warsz). 2021 Sep 14;69(1):24. doi: 10.1007/s00005-021-00628-3. Arch Immunol Ther Exp (Warsz). 2021. PMID: 34523016 Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous