Capillary electrophoresis frontal analysis: principles and applications for the study of drug-plasma protein binding
- PMID: 12973793
- DOI: 10.1002/elps.200305526
Capillary electrophoresis frontal analysis: principles and applications for the study of drug-plasma protein binding
Abstract
Capillary electrophoresis is a well-established technique for the study of noncovalent interactions. Various approaches exist and capillary electrophoresis-frontal analysis provides an interesting alternative to the migration shift affinity capillary electrophoresis methods and conventional methods. The present work reviews the principles on which the frontal analysis method is founded. Advantages and limitations of capillary electrophoresis frontal analysis in comparison with both conventional and other capillary electrophoresis based methods for quantification of binding interactions are discussed. Investigations utilizing capillary electrophoresis-frontal analysis have focused on the interaction of drugs with plasma proteins. These studies, primarily addressing the binding of drugs to human serum albumin, alpha1-acid glycoprotein, and lipoproteins are reviewed together with some recent developments in capillary electrophoresis-frontal analysis methodology.
Similar articles
-
Flow injection-capillary electrophoresis frontal analysis method for the study of the interactions of a series of drugs with human serum albumin.J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):3144-50. doi: 10.1016/j.jchromb.2009.08.002. Epub 2009 Aug 7. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19695968
-
Investigating noncovalent interactions of rutin-serum albumin by capillary electrophoresis-frontal analysis.J Pharm Biomed Anal. 2008 Aug 5;47(4-5):888-91. doi: 10.1016/j.jpba.2008.03.007. Epub 2008 Mar 15. J Pharm Biomed Anal. 2008. PMID: 18436413
-
The Hummel-Dreyer method: impact in pharmacology.Biomed Chromatogr. 2004 May;18(4):259-71. doi: 10.1002/bmc.338. Biomed Chromatogr. 2004. PMID: 15162389 Review.
-
Pharmaceutical and biomedical applications of chiral capillary electrophoresis and capillary electrochromatography: an update.Electrophoresis. 2003 Aug;24(15):2409-21. doi: 10.1002/elps.200305491. Electrophoresis. 2003. PMID: 12900851 Review.
-
Evalution of capillary electrophoresis-frontal analysis for the study of low molecular weight drug-human serum albumin interactions.Electrophoresis. 2002 Sep;23(17):2842-53. doi: 10.1002/1522-2683(200209)23:17<2842::AID-ELPS2842>3.0.CO;2-B. Electrophoresis. 2002. PMID: 12207290
Cited by
-
Determination of 3- and 4-chloromethcathinone interactions with plasma proteins: study involving analytical and theoretical methods.Forensic Toxicol. 2023 Dec 18. doi: 10.1007/s11419-023-00677-7. Online ahead of print. Forensic Toxicol. 2023. PMID: 38108940
-
Analysis of drug interactions with serum proteins and related binding agents by affinity capillary electrophoresis: A review.Electrophoresis. 2022 Dec;43(23-24):2302-2323. doi: 10.1002/elps.202200191. Epub 2022 Nov 10. Electrophoresis. 2022. PMID: 36250426 Free PMC article. Review.
-
Clinical and pharmaceutical applications of affinity ligands in capillary electrophoresis: A review.J Pharm Biomed Anal. 2020 Jan 5;177:112882. doi: 10.1016/j.jpba.2019.112882. Epub 2019 Sep 12. J Pharm Biomed Anal. 2020. PMID: 31542417 Free PMC article. Review.
-
Binding of triclosan to human serum albumin: insight into the molecular toxicity of emerging contaminant.Environ Sci Pollut Res Int. 2011 Aug;19(7):2528-36. doi: 10.1007/s11356-012-0901-5. Epub 2012 Jul 21. Environ Sci Pollut Res Int. 2011. PMID: 22828882
-
Examining the interactome of huperzine A by magnetic biopanning.PLoS One. 2012;7(5):e37098. doi: 10.1371/journal.pone.0037098. Epub 2012 May 16. PLoS One. 2012. PMID: 22615909 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical