Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination
- PMID: 14575774
- DOI: 10.1016/s0264-410x(03)00447-x
Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination
Abstract
A novel DNA vaccine against hepatitis B virus was administered intraepidermally by particle-mediated epidermal delivery (PMED) to 16 human subjects who demonstrated absent or non-sustainable responses to conventional hepatitis B vaccination. Eleven subjects received three doses of vaccine at 56-day intervals, and five subjects received only a single vaccination. Each dose of vaccine contained 4 microg of plasmid DNA encoding the hepatitis B surface antigen (HBsAg). The vaccine was safe and well tolerated. Remarkably, the DNA vaccine elicited antibody responses in 12 of the 16 subjects after a licensed subunit vaccine failed to induce a lasting response after >/=3 vaccinations. This study provides evidence in humans for protective immunogenicity of a particle-mediated DNA vaccine in subjects who have responded suboptimally to conventional vaccination.
Similar articles
-
Induction of a robust T- and B-cell immune response in non- and low-responders to conventional vaccination against hepatitis B by using a third generation PreS/S vaccine.Vaccine. 2014 Sep 3;32(39):5077-82. doi: 10.1016/j.vaccine.2014.06.076. Epub 2014 Jun 24. Vaccine. 2014. PMID: 24975813
-
[Reciprocal priming-boosting role of HBsAg and DNA vaccines].Zhonghua Gan Zang Bing Za Zhi. 2003 Apr;11(4):212-4. Zhonghua Gan Zang Bing Za Zhi. 2003. PMID: 12716517 Chinese.
-
Hepatitis B vaccination of premature infants: a reassessment of current recommendations for delayed immunization.Pediatrics. 1999 Feb;103(2):E14. doi: 10.1542/peds.103.2.e14. Pediatrics. 1999. PMID: 9925860
-
DNA-mediated immunization to the hepatitis B surface antigen. Activation and entrainment of the immune response.Ann N Y Acad Sci. 1995 Nov 27;772:64-76. doi: 10.1111/j.1749-6632.1995.tb44732.x. Ann N Y Acad Sci. 1995. PMID: 8546414 Review.
-
Correlation between in vivo humoral and in vitro cellular immune responses following immunization with hepatitis B surface antigen (HBsAg) vaccines.Vaccine. 1994 Jul;12(9):812-8. doi: 10.1016/0264-410x(94)90290-9. Vaccine. 1994. PMID: 7975860 Clinical Trial.
Cited by
-
Post-genomic platform for development of oligonucleotide vaccines against RNA viruses: diamond cuts diamond.Inflamm Res. 2022 Aug;71(7-8):729-739. doi: 10.1007/s00011-022-01582-2. Epub 2022 May 6. Inflamm Res. 2022. PMID: 35523969 Free PMC article.
-
Nanotechnologies in Delivery of DNA and mRNA Vaccines to the Nasal and Pulmonary Mucosa.Nanomaterials (Basel). 2022 Jan 11;12(2):226. doi: 10.3390/nano12020226. Nanomaterials (Basel). 2022. PMID: 35055244 Free PMC article. Review.
-
COVID-19 phase 4 vaccine candidates, effectiveness on SARS-CoV-2 variants, neutralizing antibody, rare side effects, traditional and nano-based vaccine platforms: a review.3 Biotech. 2022 Jan;12(1):15. doi: 10.1007/s13205-021-03076-0. Epub 2021 Dec 12. 3 Biotech. 2022. PMID: 34926119 Free PMC article. Review.
-
Vaccination into the Dermal Compartment: Techniques, Challenges, and Prospects.Vaccines (Basel). 2020 Sep 16;8(3):534. doi: 10.3390/vaccines8030534. Vaccines (Basel). 2020. PMID: 32947966 Free PMC article. Review.
-
N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis.Cells. 2020 Jun 4;9(6):1404. doi: 10.3390/cells9061404. Cells. 2020. PMID: 32512942 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
