Comparison of risk factors for colon and rectal cancer
- PMID: 14648711
- PMCID: PMC2903217
- DOI: 10.1002/ijc.11540
Comparison of risk factors for colon and rectal cancer
Abstract
Predictors of colorectal cancer have been extensively studied with some evidence suggesting that risk factors vary by subsite. Using data from 2 prospective cohort studies, we examined established risk factors to determine whether they were differentially associated with colon and rectal cancer. Our study population included 87,733 women from the Nurses' Health Study (NHS) and 46,632 men from the Health Professionals Follow Up Study (HPFS). Exposure information was collected via biennial questionnaires (dietary variables were collected every 4 years). During the follow-up period (NHS: 1980 to May 31, 2000; HPFS: 1986 to January 31, 2000), we identified 1,139 cases of colon cancer and 339 cases of rectal cancer. We used pooled logistic regression to estimate multivariate relative risks for the 2 outcomes separately and then used polytomous logistic regression to compare these estimates. In the combined cohort, age, gender, family history of colon or rectal cancer, height, body mass index, physical activity, folate, intake of beef, pork or lamb as a main dish, intake of processed meat and alcohol were significantly associated with colon cancer risk. However, only age and sex were associated with rectal cancer. In a stepwise polytomous logistic regression procedure, family history and physical activity were associated with statistically significant different relative risks of colon and rectal cancer. Our findings support previous suggestions that family history and physical activity are not strong contributors to the etiology of rectal cancer. Future investigations of colon or rectal cancer should take into consideration risk factor differences by subsite.
Copyright 2003 Wiley-Liss, Inc.
Comment in
-
Familial risk for colon and rectal cancers.Int J Cancer. 2004 Sep 20;111(5):809-10. doi: 10.1002/ijc.20341. Int J Cancer. 2004. PMID: 15252856 No abstract available.
Similar articles
-
Meat consumption and risk of colorectal cancer.JAMA. 2005 Jan 12;293(2):172-82. doi: 10.1001/jama.293.2.172. JAMA. 2005. PMID: 15644544
-
Red meat intake may increase the risk of colon cancer in Japanese, a population with relatively low red meat consumption.Asia Pac J Clin Nutr. 2011;20(4):603-12. Asia Pac J Clin Nutr. 2011. PMID: 22094846
-
Red meat consumption and risk of cancers of the proximal colon, distal colon and rectum: the Swedish Mammography Cohort.Int J Cancer. 2005 Feb 20;113(5):829-34. doi: 10.1002/ijc.20658. Int J Cancer. 2005. PMID: 15499619
-
Domain-specific physical activity and sedentary behaviour in relation to colon and rectal cancer risk: a systematic review and meta-analysis.Int J Epidemiol. 2017 Dec 1;46(6):1797-1813. doi: 10.1093/ije/dyx137. Int J Epidemiol. 2017. PMID: 29025130 Review.
-
Gender and colorectal cancer.Eur J Cancer Prev. 1993 Mar;2(2):105-15. doi: 10.1097/00008469-199303000-00003. Eur J Cancer Prev. 1993. PMID: 8461861 Review.
Cited by
-
Readjustment of nodal staging by integrating tumor deposits and positive lymph nodes in patients with stage III colon cancer: a population-based analysis.Am J Cancer Res. 2023 Oct 15;13(10):4976-4988. eCollection 2023. Am J Cancer Res. 2023. PMID: 37970348 Free PMC article.
-
Low Incidence of Colorectal Advanced Neoplasia During Surveillance in Individuals with a Family History of Colorectal Cancer.Dig Dis Sci. 2023 Nov;68(11):4243-4251. doi: 10.1007/s10620-023-08053-6. Epub 2023 Sep 8. Dig Dis Sci. 2023. PMID: 37682374 Free PMC article.
-
Association of meat consumption with the risk of gastrointestinal cancers: a systematic review and meta-analysis.BMC Cancer. 2023 Aug 23;23(1):782. doi: 10.1186/s12885-023-11218-1. BMC Cancer. 2023. PMID: 37612616 Free PMC article.
-
Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising Condition.Cancers (Basel). 2023 Jul 5;15(13):3509. doi: 10.3390/cancers15133509. Cancers (Basel). 2023. PMID: 37444619 Free PMC article. Review.
-
Rectal Cancer: Are 12 Lymph Nodes the Limit?Cancers (Basel). 2023 Jun 30;15(13):3447. doi: 10.3390/cancers15133447. Cancers (Basel). 2023. PMID: 37444557 Free PMC article.
References
-
- Chyou P, Nomura A, Stemmermann G. A prospective study of colon and rectal cancer among Hawaii Japanese Men. Ann Epidemiol. 1996;6:276–282. - PubMed
-
- Bonithon-Kopp C, Benhamiche A. Are there several colorectal cancers? Epidemiological data. Eur J Cancer Prevention. 1999;8:S3–S12. - PubMed
-
- Young TB, Wolf DA. Case-control study of proximal and distal colon cancer and diet in Wisconsin. Int J Cancer. 1988;42:167–175. - PubMed
-
- Wu K, Willett WC, Fuchs CS, Colditz GA, Giovannucci EL. Calcium Intake and risk of colon cancer in women and men. J Nat Cancer Inst. 2002;94:437–446. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical