doi: 10.1126/science.1496383.
Participation in normal immune responses of a metastasis-inducing splice variant of CD44
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- PMID: 1496383
- DOI: 10.1126/science.1496383
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Participation in normal immune responses of a metastasis-inducing splice variant of CD44
Science.
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Abstract
A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T lymphocytes and macrophages after antigenic stimulation and in the postnatal period. Antibodies to the variant hinder in vivo activation of both B and T cells. The observation that a protein domain that is expressed on CD44 and required for the lymphatic spread of tumor cells can catalyze an essential step in the process of lymphocyte activation supports the idea that metastasizing tumor cells mimic lymphocyte behavior.
Comment in
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Adhesion protein studies provide new clue to metastasis.Science. 1992 Jul 31;257(5070):614. doi: 10.1126/science.1496370. Science. 1992. PMID: 1496370 No abstract available.
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