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Review
. 2004 Jan;255(1-2):67-78.
doi: 10.1023/b:mcbi.0000007262.26044.e8.

Oxidative mechanism of arsenic toxicity and carcinogenesis

Honglian Shi  1 , Xianglin Shi, Ke Jian Liu
Affiliations
Review

Oxidative mechanism of arsenic toxicity and carcinogenesis

Honglian Shi et al. Mol Cell Biochem. 2004 Jan.

Abstract

Arsenic is a known toxin and carcinogen that is present in industrial settings and in the environment. The mechanisms of disease initiation and progression are not fully understood. In the last a few years, there has been increasing evidence of the correlation between the generation of reactive oxygen species (ROS), DNA damage, tumor promotion, and arsenic exposure. This article summarizes the current literature on the arsenic mediated generation of ROS and reactive nitrogen species (RNS) in various biological systems. This article also discusses the role of ROS and RNS in arsenic-induced DNA damage and activation of oxidative sensitive gene expression.

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References

    1. Indian J Gastroenterol. 2000 Jul-Sep;19(3):112-5 - PubMed
    1. Environ Res. 1983 Oct;32(1):14-24 - PubMed
    1. Epidemiol Rev. 1994;16(2):184-209 - PubMed
    1. Br J Haematol. 1998 Dec;103(3):721-8 - PubMed
    1. Mutat Res. 1997 Jun;386(3):209-18 - PubMed

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