Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Sep;30(9):1834-7.
doi: 10.1007/s00134-004-2233-5. Epub 2004 Mar 25.

The respiratory variation in inferior vena cava diameter as a guide to fluid therapy

Marc Feissel  1 , Frédéric Michard, Jean-Pierre Faller, Jean-Louis Teboul
Affiliations

The respiratory variation in inferior vena cava diameter as a guide to fluid therapy

Marc Feissel et al. Intensive Care Med. 2004 Sep.

Abstract

Objective: To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients.

Design: Prospective clinical study.

Setting: Medical ICU of a non-university hospital.

Patients: Mechanically ventilated patients with septic shock (n=39).

Interventions: Volume loading with 8 mL/kg of 6% hydroxyethylstarch over 20 min.

Measurements and results: Cardiac output and DeltaD(IVC) were assessed by echography before and immediately after the standardized volume load. Volume loading induced an increase in cardiac output from 5.7+/-2.0 to 6.4+/-1.9 L/min (P<0.001) and a decrease in DeltaD(IVC) from 13.8+/-13.6 vs 5.2+/-5.8% (P<0.001). Sixteen patients responded to volume loading by an increase in cardiac output > or =15% (responders). Before volume loading, the DeltaD(IVC) was greater in responders than in non-responders (25+/-15 vs 6+/-4%, P<0.001), closely correlated with the increase in cardiac output (r=0.82, P<0.001), and a 12% DeltaD(IVC) cut-off value allowed identification of responders with positive and negative predictive values of 93% and 92%, respectively.

Conclusion: Analysis of DeltaD(IVC) is a simple and non-invasive method to detect fluid responsiveness in mechanically ventilated patients with septic shock.

PubMed Disclaimer

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Am Rev Respir Dis. 1979 Aug;120(2):421-7 - PubMed
    1. Intensive Care Med. 2003 Sep;29(9):1613 - PubMed
    1. Cardiovasc Res. 1994 Apr;28(4):472-9 - PubMed
    1. J Appl Physiol. 1961 Jan;16:64-70 - PubMed
    1. Am J Respir Crit Care Med. 2003 Sep 15;168(6):671-6 - PubMed

LinkOut - more resources

-