Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women
- PMID: 15465752
- DOI: 10.1093/jn/134.10.2586
Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women
Abstract
Prenatal anemia and iron deficiency are associated with adverse birth outcomes, but no previous studies have examined the relation between preconception anemia, iron deficiency, and pregnancy outcome in healthy women. We measured hemoglobin (Hb), ferritin, transferrin receptor (TfR), and vitamins B-6, B-12, and folate concentrations before pregnancy in 405 Chinese women (median time from sample collection to gestation end = 316 d). Both mild (95 </= Hb < 120 g/L) and moderate (Hb < 95 g/L) anemia were significantly associated with lower birthweight (139 and 192 g, respectively); iron-deficiency anemia alone (Hb < 120 g, ferritin < 12 microg/L, no B-vitamin deficiency) was associated with a 242-g decrease in birthweight. Both low (<12 microg/L) and high (>/=60 microg/L) ferritin were also significantly associated with lower birthweight (106 and 123 g, respectively). The risks of low birthweight (LBW) and fetal growth restriction (FGR) were significantly greater among women with moderate anemia compared with nonanemic controls [odds ratio (OR): 6.5; 95% CI: 1.6, 26.7; P = 0.009 and OR: 4.6; 95% CI: 1.5, 13.5; P = 0.006, respectively]. TfR and low ferritin were not associated with adverse birth outcome, but elevated ferritin, which could be a marker of inflammation, was associated with increased risk of LBW (OR: 2.2; 95% CI: 0.9, 5.7; P = 0.09) and FGR (OR: 2.7; 95% CI: 1.3, 5.6; P = 0.008). Preconception anemia, particularly iron-deficiency anemia, was associated with reduced infant growth and increased risk of adverse pregnancy outcome in Chinese women.
Similar articles
-
Iron Supplementation Affects Hematologic Biomarker Concentrations and Pregnancy Outcomes among Iron-Deficient Tanzanian Women.J Nutr. 2016 Jun;146(6):1162-71. doi: 10.3945/jn.115.225482. Epub 2016 Apr 27. J Nutr. 2016. PMID: 27121530 Free PMC article.
-
Anemia and deficiencies of folate and vitamin B-6 are common and vary with season in Chinese women of childbearing age.J Nutr. 2000 Nov;130(11):2703-10. doi: 10.1093/jn/130.11.2703. J Nutr. 2000. PMID: 11053510
-
Preconception Hemoglobin Concentration and Risk of Low Birth Weight and Small-for-Gestational-Age: A Large Prospective Cohort Study in China.Nutrients. 2022 Jan 9;14(2):271. doi: 10.3390/nu14020271. Nutrients. 2022. PMID: 35057452 Free PMC article.
-
[Review by expert group in the diagnosis and treatment of anemia in pregnant women. Federación Mexicana de Colegios de Obstetricia y Ginecología].Ginecol Obstet Mex. 2012 Sep;80(9):563-80. Ginecol Obstet Mex. 2012. PMID: 23243836 Spanish.
-
Intermittent oral iron supplementation during pregnancy.Cochrane Database Syst Rev. 2015 Oct 19;2015(10):CD009997. doi: 10.1002/14651858.CD009997.pub2. Cochrane Database Syst Rev. 2015. PMID: 26482110 Free PMC article. Review.
Cited by
-
The ORIGINS Project: A Cross-Sectional Analysis of the Nutrition Profile of Pregnant Women in a Longitudinal Birth Cohort.Nutrients. 2024 Aug 5;16(15):2571. doi: 10.3390/nu16152571. Nutrients. 2024. PMID: 39125450 Free PMC article.
-
Association of soluble transferrin receptor/log ferritin index with all-cause and cause-specific mortality: National Health and Nutrition Examination Survey.Front Nutr. 2024 Feb 27;11:1275522. doi: 10.3389/fnut.2024.1275522. eCollection 2024. Front Nutr. 2024. PMID: 38476599 Free PMC article.
-
Determinants of anemia level among reproductive-age women in 29 Sub-Saharan African countries: A multilevel mixed-effects modelling with ordered logistic regression analysis.PLoS One. 2023 Nov 29;18(11):e0294992. doi: 10.1371/journal.pone.0294992. eCollection 2023. PLoS One. 2023. PMID: 38019840 Free PMC article.
-
Maternal low and high hemoglobin concentrations and associations with adverse maternal and infant health outcomes: an updated global systematic review and meta-analysis.BMC Pregnancy Childbirth. 2023 Apr 19;23(1):264. doi: 10.1186/s12884-023-05489-6. BMC Pregnancy Childbirth. 2023. PMID: 37076797 Free PMC article.
-
Long-Term Association Between Maternal Preconception Hemoglobin Concentration, Anemia, and Child Health and Development in Vietnam.J Nutr. 2023 May;153(5):1597-1606. doi: 10.1016/j.tjnut.2023.03.015. Epub 2023 Mar 15. J Nutr. 2023. PMID: 36925072 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous