Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-I alpha)
- PMID: 15469941
- DOI: 10.1074/jbc.M406028200
Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-I alpha)
Abstract
Carnitine palmitoyltransferase I (CPT-I) catalyzes the rate-controlling step in the pathway of mitochondrial fatty acid oxidation. Thyroid hormone will stimulate the expression of the liver isoform of CPT-I (CPT-I alpha). This induction of CPT-I alpha gene expression requires the thyroid hormone response element in the promoter and sequences within the first intron. The peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) is a coactivator that promotes mitochondrial biogenesis, mitochondrial fatty acid oxidation, and hepatic gluconeogenesis. In addition, PGC-1 alpha will stimulate the expression of CPT-I alpha in primary rat hepatocytes. Here we report that thyroid hormone will increase PGC-1 alpha mRNA and protein levels in rat hepatocytes. In addition, overexpression of PGC-1 alpha will enhance the thyroid hormone induction of CPT-I alpha indicating that PGC-1 alpha is a coactivator for thyroid hormone. By using chromatin immunoprecipitation assays, we show that PGC-1 alpha is associated with both the thyroid hormone response element in the CPT-I alpha gene promoter and the first intron of the CPT-I alpha gene. Our data demonstrate that PGC-1 alpha participates in the stimulation of CPT-I alpha gene expression by thyroid hormone and suggest that PGC-1 alpha is a coactivator for thyroid hormone.
Similar articles
-
Regulation of carnitine palmitoyltransferase I (CPT-Ialpha) gene expression by the peroxisome proliferator activated receptor gamma coactivator (PGC-1) isoforms.Mol Cell Endocrinol. 2007 Mar 15;267(1-2):6-16. doi: 10.1016/j.mce.2006.11.012. Epub 2006 Dec 16. Mol Cell Endocrinol. 2007. PMID: 17239528 Free PMC article.
-
Peroxisomal proliferator activated receptor gamma coactivator (PGC-1alpha) stimulates carnitine palmitoyltransferase I (CPT-Ialpha) through the first intron.Biochim Biophys Acta. 2004 Aug 12;1679(2):164-73. doi: 10.1016/j.bbaexp.2004.06.006. Biochim Biophys Acta. 2004. PMID: 15297149
-
A thyroid hormone response unit formed between the promoter and first intron of the carnitine palmitoyltransferase-Ialpha gene mediates the liver-specific induction by thyroid hormone.J Biol Chem. 2003 Mar 7;278(10):7964-72. doi: 10.1074/jbc.M211062200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12493735
-
Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids.Biochem Soc Trans. 2001 May;29(Pt 2):310-6. doi: 10.1042/0300-5127:0290310. Biochem Soc Trans. 2001. PMID: 11356173 Review.
-
Expression and regulation of carnitine palmitoyltransferase-Ialpha and -Ibeta genes.Am J Med Sci. 1999 Jul;318(1):43-8. doi: 10.1097/00000441-199907000-00007. Am J Med Sci. 1999. PMID: 10408760 Review.
Cited by
-
Metabolic Roles of HIF1, c-Myc, and p53 in Glioma Cells.Metabolites. 2024 Apr 25;14(5):249. doi: 10.3390/metabo14050249. Metabolites. 2024. PMID: 38786726 Free PMC article. Review.
-
PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice.Transl Neurosci. 2023 Nov 15;14(1):20220317. doi: 10.1515/tnsci-2022-0317. eCollection 2023 Jan 1. Transl Neurosci. 2023. PMID: 38023298 Free PMC article.
-
Mitochondrial CPT1A: Insights into structure, function, and basis for drug development.Front Pharmacol. 2023 Mar 23;14:1160440. doi: 10.3389/fphar.2023.1160440. eCollection 2023. Front Pharmacol. 2023. PMID: 37033619 Free PMC article. Review.
-
Dietary Histidine Supplementation Maintained Amino Acid Homeostasis and Reduced Hepatic Lipid Accumulation of Juvenile Largemouth Bass, Micropterus Salmoides.Aquac Nutr. 2022 Oct 25;2022:4034922. doi: 10.1155/2022/4034922. eCollection 2022. Aquac Nutr. 2022. PMID: 36860443 Free PMC article.
-
Thyroid hormone signaling in the intestinal stem cells and their niche.Cell Mol Life Sci. 2022 Aug 10;79(9):476. doi: 10.1007/s00018-022-04503-y. Cell Mol Life Sci. 2022. PMID: 35947210 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources