doi: 10.1021/jm0493008.
Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus
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- PMID: 15715493
- DOI: 10.1021/jm0493008
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Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus
J Med Chem.
.
Abstract
Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-beta-d-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.
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