Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population
- PMID: 15766558
- PMCID: PMC7092916
- DOI: 10.1016/j.bbrc.2005.02.101
Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population
Abstract
We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2',5'-oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p=0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p=0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.
Similar articles
-
Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study.BMC Infect Dis. 2006 Jul 6;6:106. doi: 10.1186/1471-2334-6-106. BMC Infect Dis. 2006. PMID: 16824203 Free PMC article.
-
Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR.Genes Immun. 2003 Sep;4(6):411-9. doi: 10.1038/sj.gene.6363984. Genes Immun. 2003. PMID: 12944978
-
IL-29 and IFN-α regulate the expression of MxA, 2',5'-OAS and PKR genes in association with the activation of Raf-MEK-ERK and PI3K-AKT signal pathways in HepG2.2.15 cells.Mol Biol Rep. 2011 Jan;38(1):139-43. doi: 10.1007/s11033-010-0087-1. Epub 2010 Mar 23. Mol Biol Rep. 2011. PMID: 20309637
-
[Alpha interferon, antiviral proteins and their value in clinical medicine].Ann Biol Clin (Paris). 1999 Nov-Dec;57(6):659-66. Ann Biol Clin (Paris). 1999. PMID: 10572214 Review. French.
-
The human 2',5'-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties.J Interferon Cytokine Res. 1999 Apr;19(4):295-308. doi: 10.1089/107999099313992. J Interferon Cytokine Res. 1999. PMID: 10334380 Review.
Cited by
-
Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19.BMC Infect Dis. 2024 Mar 1;24(1):270. doi: 10.1186/s12879-024-09040-6. BMC Infect Dis. 2024. PMID: 38429664 Free PMC article.
-
Multi-phasic gene profiling using candidate gene approach predict the capacity of specific antibody production and maintenance following COVID-19 vaccination in Japanese population.Front Immunol. 2023 Jul 26;14:1217206. doi: 10.3389/fimmu.2023.1217206. eCollection 2023. Front Immunol. 2023. PMID: 37564647 Free PMC article.
-
Genetic Ethnic Differences in Human 2'-5'-Oligoadenylate Synthetase and Disease Associations: A Systematic Review.Genes (Basel). 2023 Feb 19;14(2):527. doi: 10.3390/genes14020527. Genes (Basel). 2023. PMID: 36833454 Free PMC article. Review.
-
Host methylation predicts SARS-CoV-2 infection and clinical outcome.Commun Med (Lond). 2021 Oct 26;1(1):42. doi: 10.1038/s43856-021-00042-y. Commun Med (Lond). 2021. PMID: 36750622
-
Targeted screening of genetic associations with COVID-19 susceptibility and severity.Front Genet. 2022 Nov 30;13:1073880. doi: 10.3389/fgene.2022.1073880. eCollection 2022. Front Genet. 2022. PMID: 36531218 Free PMC article.
References
-
- World Health Organization (2003), Consensus document on the epidemiology of severe acute respiratory syndrome (SARS), WHO/CDS/CSR/GAR/2003.11, Geneva
-
- Booth C.M., Matukas L.M., Tomlinson G.A., Rachlis A.R., Rose D.B., Dwosh H.A., Walmsley S.L., Mazzulli T., Avendano M., Derkach P., Ephtimios I.E., Kitai I., Mederski B.D., Shadowitz S.B., Gold W.L., Hawryluck L.A., Rea E., Chenkin J.S., Cescon D.W., Poutanen S.M., Detsky A.S. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. Jama. 2003;289:2801–2809. - PubMed
-
- Ng M.H., Lau K.M., Li L., Cheng S.H., Chan W.Y., Hui P.K., Zee B., Leung C.B., Sung J.J. Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome. J. Infect. Dis. 2004;190:515–518. - PMC - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous