doi: 10.1016/j.jocn.2004.12.002.
Increased xanthine oxidase activity after traumatic brain injury in rats
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- PMID: 15851081
- DOI: 10.1016/j.jocn.2004.12.002
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Increased xanthine oxidase activity after traumatic brain injury in rats
J Clin Neurosci.
2005 Apr.
Abstract
Oxidative stress may contribute to many of the pathophysiologic changes that occur after traumatic brain injury (TBI). There are a number of potential sources and mechanisms for oxygen free radical (OFR) production and lipid peroxidation after TBI. In this study, we investigate the time-dependent changes in xanthine oxidase (XO) activity and lipid peroxidation using a focal TBI animal model. We demonstrate that there is an immediate increase in lipid peroxidation by-products and in XO enzyme activity after TBI.
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