Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity
- PMID: 15982990
- DOI: 10.1177/0269881105053286
Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity
Abstract
Single doses of the traditional herbal treatment Panax ginseng have recently been shown to elicit cognitive improvements in healthy young volunteers. The mechanisms by which ginseng improves cognitive performance are not known. However, they may be related to the glycaemic properties of some Panax species. Using a double-blind, placebo-controlled, balanced crossover design, 30 healthy young adults completed a 10 min test battery at baseline, and then six times in immediate succession commencing 60 min after the day's treatment (placebo, 200mg G115 or 400mg G115). The 10 min battery comprised a Serial Threes subtraction task (2 min); a Serial Sevens task (2 min); a Rapid Visual Information Processing task (5 min); then a 'mental fatigue' visual analogue scale. Blood glucose was measured prior to each day's treatment, and before, during and after the post-dose completions of the battery. Both the 200mg and 400mg treatments led to significant reductions in blood glucose levels at all three post-treatment measurements (p 0.005 in all cases). The most notable behavioural effects were associated with 200mg of ginseng and included significantly improved Serial Sevens subtraction task performance and significantly reduced subjective mental fatigue throughout all (with the exception of one time point in each case) of the post-dose completions of the 10 min battery (p 0.05). Overall these data suggest that Panax ginseng can improve performance and subjective feelings of mental fatigue during sustained mental activity. This effect may be related to the acute gluco-regulatory properties of the extract.
Similar articles
-
The G115 standardized ginseng extract: an example for safety, efficacy, and quality of an herbal medicine.J Ginseng Res. 2020 Mar;44(2):179-193. doi: 10.1016/j.jgr.2019.06.003. Epub 2019 Jun 18. J Ginseng Res. 2020. PMID: 32148399 Free PMC article. Review.
-
Cognitive and psychomotor effects of risperidone in schizophrenia and schizoaffective disorder.Clin Ther. 2008 Sep;30(9):1565-89. doi: 10.1016/j.clinthera.2008.09.014. Clin Ther. 2008. PMID: 18840365 Review.
-
Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks.J Psychopharmacol. 2006 Nov;20(6):771-81. doi: 10.1177/0269881106061516. Epub 2006 Jan 9. J Psychopharmacol. 2006. PMID: 16401645 Clinical Trial.
-
Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng.Pharmacol Biochem Behav. 2004 Nov;79(3):401-11. doi: 10.1016/j.pbb.2004.07.014. Pharmacol Biochem Behav. 2004. PMID: 15582012 Clinical Trial.
-
Acute, dose-dependent cognitive effects of Ginkgo biloba, Panax ginseng and their combination in healthy young volunteers: differential interactions with cognitive demand.Hum Psychopharmacol. 2002 Jan;17(1):35-44. doi: 10.1002/hup.352. Hum Psychopharmacol. 2002. PMID: 12404705 Clinical Trial.
Cited by
-
Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia.J Ginseng Res. 2024 May;48(3):245-252. doi: 10.1016/j.jgr.2024.02.002. Epub 2024 Feb 17. J Ginseng Res. 2024. PMID: 38707644 Free PMC article. Review.
-
Ginsenosides Decrease β-Amyloid Production via Potentiating Capacitative Calcium Entry.Biomol Ther (Seoul). 2024 May 1;32(3):301-308. doi: 10.4062/biomolther.2023.172. Epub 2024 Apr 9. Biomol Ther (Seoul). 2024. PMID: 38586949 Free PMC article.
-
Acute Cognitive Performance and Mood Effects of Coffeeberry Extract: A Randomized, Double Blind, Placebo-Controlled Crossover Study in Healthy Humans.Nutrients. 2023 May 23;15(11):2418. doi: 10.3390/nu15112418. Nutrients. 2023. PMID: 37299382 Free PMC article. Clinical Trial.
-
A novel protocol for batch-separating gintonin-enriched, polysaccharide-enriched, and crude ginsenoside-containing fractions from Panax ginseng.J Ginseng Res. 2023 May;47(3):366-375. doi: 10.1016/j.jgr.2022.10.001. Epub 2022 Oct 20. J Ginseng Res. 2023. PMID: 37252285 Free PMC article.
-
Mental Performance and Sport: Caffeine and Co-consumed Bioactive Ingredients.Sports Med. 2022 Dec;52(Suppl 1):69-90. doi: 10.1007/s40279-022-01796-8. Epub 2022 Nov 30. Sports Med. 2022. PMID: 36447122 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical