PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking
- PMID: 16055064
- DOI: 10.1016/j.neuron.2005.07.006
PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking
Abstract
PICK1 and ABP/GRIP bind to the AMPA receptor (AMPAR) GluR2 subunit C terminus. Transfer of the receptor from ABP/GRIP to PICK1, facilitated by GluR2 S880 phosphorylation, may initiate receptor trafficking. Here we report protein interactions that regulate these steps. The PICK1 BAR domain interacts intermolecularly with the ABP/GRIP linker II region and intramolecularly with the PICK1 PDZ domain. Binding of PKCalpha or GluR2 to the PICK1 PDZ domain disrupts the intramolecular interaction and facilitates the PICK1 BAR domain association with ABP/GRIP. Interference with the PICK1-ABP/GRIP interaction impairs S880 phosphorylation of GluR2 by PKC and decreases the constitutive surface expression of GluR2, the NMDA-induced endocytosis of GluR2, and recycling of internalized GluR2. We suggest that the PICK1 interaction with ABP/GRIP is a critical step in controlling GluR2 trafficking.
Similar articles
-
PICK1: a multi-talented modulator of AMPA receptor trafficking.Pharmacol Ther. 2008 Apr;118(1):152-60. doi: 10.1016/j.pharmthera.2008.02.002. Epub 2008 Feb 20. Pharmacol Ther. 2008. PMID: 18353440 Review.
-
Differential regulation of AMPA receptor trafficking by neurabin-targeted synaptic protein phosphatase-1 in synaptic transmission and long-term depression in hippocampus.J Neurosci. 2007 Apr 25;27(17):4674-86. doi: 10.1523/JNEUROSCI.5365-06.2007. J Neurosci. 2007. PMID: 17460080 Free PMC article.
-
Structure and function of PICK1.Neurosignals. 2006-2007;15(4):190-201. doi: 10.1159/000098482. Epub 2007 Jan 11. Neurosignals. 2006. PMID: 17215589 Review.
-
N-methyl-D-aspartate-induced alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor down-regulation involves interaction of the carboxyl terminus of GluR2/3 with Pick1. Ligand-binding studies using Sindbis vectors carrying AMPA receptor decoys.J Biol Chem. 2001 Oct 26;276(43):40025-32. doi: 10.1074/jbc.M103125200. Epub 2001 Aug 9. J Biol Chem. 2001. PMID: 11498531
-
PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2.J Neurosci. 2001 Aug 1;21(15):5417-28. doi: 10.1523/JNEUROSCI.21-15-05417.2001. J Neurosci. 2001. PMID: 11466413 Free PMC article.
Cited by
-
Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes.ACS Chem Neurosci. 2024 May 15;15(10):2070-2079. doi: 10.1021/acschemneuro.4c00138. Epub 2024 May 1. ACS Chem Neurosci. 2024. PMID: 38691676 Free PMC article.
-
Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System.Int J Mol Sci. 2023 Dec 21;25(1):111. doi: 10.3390/ijms25010111. Int J Mol Sci. 2023. PMID: 38203282 Free PMC article. Review.
-
PDI augments kainic acid-induced seizure activity and neuronal death by inhibiting PP2A-GluA2-PICK1-mediated AMPA receptor internalization in the mouse hippocampus.Sci Rep. 2023 Aug 25;13(1):13927. doi: 10.1038/s41598-023-41014-7. Sci Rep. 2023. PMID: 37626185 Free PMC article.
-
Muscarinic acetylcholine receptor-dependent and NMDA receptor-dependent LTP and LTD share the common AMPAR trafficking pathway.iScience. 2023 Feb 3;26(3):106133. doi: 10.1016/j.isci.2023.106133. eCollection 2023 Mar 17. iScience. 2023. PMID: 36866246 Free PMC article.
-
Kaixin-San improves Aβ-induced synaptic plasticity inhibition by affecting the expression of regulation proteins associated with postsynaptic AMPAR expression.Front Pharmacol. 2023 Feb 14;14:1079400. doi: 10.3389/fphar.2023.1079400. eCollection 2023. Front Pharmacol. 2023. PMID: 36865910 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases