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Comparative Study
. 2005 Dec;234(4):948-60.
doi: 10.1002/dvdy.20591.

Analysis of the regulation of lin-41 during chick and mouse limb development

Joseph J Lancman  1 , Nicholas C Caruccio, Brian D Harfe, Amy E Pasquinelli, Jeoffrey J Schageman, Alexander Pertsemlidis, John F Fallon
Affiliations
Free article
Comparative Study

Analysis of the regulation of lin-41 during chick and mouse limb development

Joseph J Lancman et al. Dev Dyn. 2005 Dec.
Free article

Abstract

We have cloned the chicken and mouse orthologues of the Caenorhabditis elegans heterochronic gene lin-41. During limb development, lin-41 is expressed in three phases over developmental time and most notably is associated with the developing autopod. Using chicken and mouse mutants and bead implantations, we report that lin-41 is genetically and biochemically downstream of both the Shh and Fgf signaling pathways. In C. elegans, it is proposed that lin-41 activity is temporally regulated by miRNAs (let-7 and lin-4) that bind to complementary sites in the lin-41 3'-untranslated region (UTR). Taking a bioinformatics approach, we also report the presence of potential miRNA binding sites in the 3'-UTR of chicken lin-41, including sites for the chicken orthologues of both C. elegans let-7 and lin-4. Finally, we show that these miRNAs and others are expressed in the chick limb consistent with the hypothesis that they regulate chicken Lin-41 activity in vivo.

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