Wheel running as a predictor of cocaine self-administration and reinstatement in female rats
- PMID: 16337260
- DOI: 10.1016/j.pbb.2005.10.015
Wheel running as a predictor of cocaine self-administration and reinstatement in female rats
Abstract
Avidity for behaviors mediated by nondrug rewards, such as novelty seeking or intake of sweets or fats, is predictive of enhanced vulnerability to the locomotor-activating and rewarding effects of drugs of abuse. The purpose of the present study was to determine whether avidity for wheel running was predictive of subsequent cocaine-induced locomotor activity, cocaine self-administration, and cocaine-seeking behavior in rats. Rats with high (HiR) and low (LoR) levels of wheel running were selected from an outbred sample of Wistar rats. These rats were first tested for their locomotor response to an acute injection of cocaine (10 mg/kg, i.p.). Subsequently, a multi-phase self-administration procedure was used to examine the effect of wheel running on the maintenance, extinction, and cocaine-induced reinstatement of cocaine-seeking behavior in HiR and LoR rats. The results indicate no significant differences between HiR and LoR rats in the cocaine-induced stimulation of locomotor activity. During maintenance, HiR rats self-administered more cocaine than LoR rats. While there were no group differences in saline self-administration behavior during extinction, HiR rats showed higher cocaine-induced reinstatement than LoR rats. Rats that were previously high responders to novelty (day 1 in locomotor track) also showed significantly higher reinstatement than low novelty responders. These results suggest that a propensity for wheel running is associated with increased vulnerability for cocaine self-administration and reinstatement and that HiR rats are more motivated than LoR rats to seek cocaine.
Similar articles
-
Reduction of extinction and reinstatement of cocaine seeking by wheel running in female rats.Psychopharmacology (Berl). 2010 Mar;209(1):113-25. doi: 10.1007/s00213-010-1776-0. Epub 2010 Jan 30. Psychopharmacology (Berl). 2010. PMID: 20112008 Free PMC article.
-
Impulsive choice as a predictor of acquisition of IV cocaine self- administration and reinstatement of cocaine-seeking behavior in male and female rats.Exp Clin Psychopharmacol. 2008 Apr;16(2):165-77. doi: 10.1037/1064-1297.16.2.165. Exp Clin Psychopharmacol. 2008. PMID: 18489020
-
Stimulation of 5-HT2C receptors attenuates cue and cocaine-primed reinstatement of cocaine-seeking behavior in rats.Behav Pharmacol. 2007 Dec;18(8):791-800. doi: 10.1097/FBP.0b013e3282f1c94b. Behav Pharmacol. 2007. PMID: 17989517
-
Effects of progesterone on the reinstatement of cocaine-seeking behavior in female rats.Exp Clin Psychopharmacol. 2007 Oct;15(5):472-80. doi: 10.1037/1064-1297.15.5.472. Exp Clin Psychopharmacol. 2007. PMID: 17924781
-
Effect of short- vs. long-term estrogen on reinstatement of cocaine-seeking behavior in female rats.Pharmacol Biochem Behav. 2005 Sep;82(1):98-108. doi: 10.1016/j.pbb.2005.07.015. Epub 2005 Aug 18. Pharmacol Biochem Behav. 2005. PMID: 16111740
Cited by
-
Reducing short- and long-term cocaine craving with voluntary exercise in male rats.Psychopharmacology (Berl). 2022 Dec;239(12):3819-3831. doi: 10.1007/s00213-022-06251-0. Epub 2022 Nov 4. Psychopharmacology (Berl). 2022. PMID: 36331585
-
Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders.J Neurosci Res. 2022 Aug;100(8):1602-1642. doi: 10.1002/jnr.24990. Epub 2021 Dec 1. J Neurosci Res. 2022. PMID: 34850988 Free PMC article. Review.
-
Health Benefits of Exercise.Cold Spring Harb Perspect Med. 2018 Jul 2;8(7):a029694. doi: 10.1101/cshperspect.a029694. Cold Spring Harb Perspect Med. 2018. PMID: 28507196 Free PMC article. Review.
-
Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running.Drug Alcohol Depend. 2016 Oct 1;167:163-8. doi: 10.1016/j.drugalcdep.2016.08.020. Epub 2016 Aug 21. Drug Alcohol Depend. 2016. PMID: 27567437 Free PMC article.
-
How to study sex differences in addiction using animal models.Addict Biol. 2016 Sep;21(5):1007-29. doi: 10.1111/adb.12400. Epub 2016 Jun 26. Addict Biol. 2016. PMID: 27345022 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources