Diet quality is associated with the risk of estrogen receptor-negative breast cancer in postmenopausal women
- PMID: 16424129
- DOI: 10.1093/jn/136.2.466
Diet quality is associated with the risk of estrogen receptor-negative breast cancer in postmenopausal women
Abstract
Emerging evidence suggests that diet quality indices may serve as prognostic indicators of disease. However, the ability of these indices to predict breast cancer risk has not been evaluated previously. We assessed the association between several diet quality scores and the risk of breast cancer in postmenopausal women. The indices we used were the Healthy Eating Index (HEI), Alternate Healthy Eating Index (AHEI), Diet Quality Index-Revised (DQI-R), Recommended Food Score (RFS), and the alternate Mediterranean Diet Score (aMed). We calculated diet quality indices from dietary information collected in FFQ administered 5 times between 1984 and 1998 among women in the Nurses' Health Study cohort. Relative risks (RR) were computed using Cox proportional hazards models and adjusted for known risk factors for breast cancer. Separate analyses were conducted for estrogen receptor positive (ER+) and negative (ER-) tumors. Between 1984 and 2002, we documented 3,580 cases of breast cancer, of which 2,367 were ER+, and 575 were ER-. We did not observe any association between the diet quality indices and total or ER+ breast cancer risk. However, for ER- breast cancer, after adjusting for potential confounders, the RR comparing highest to lowest quintiles were 0.78 (95% CI=0.59-1.04, P for trend=0.01) for the AHEI, 0.69 (95% CI=0.51-0.94, P for trend=0.003) for the RFS, and 0.79 (95% CI=0.60-1.03, P for trend=0.03) for the aMed. These observations appeared to be the result of an inverse association (P for trend=0.01) with the vegetable component of the scores. We conclude that women who scored high in AHEI, RFS, and aMed had a lower risk of ER- breast cancer. The HEI and DQI-R appeared to be of limited value in predicting breast cancer risk.
Similar articles
-
Epidemiology and Risk Factors for Breast Cancer: 21st Century Advances, Gaps to Address through Interdisciplinary Science.Cold Spring Harb Perspect Med. 2023 Sep 1;13(9):a041317. doi: 10.1101/cshperspect.a041317. Cold Spring Harb Perspect Med. 2023. PMID: 36781224 Review.
-
Dietary index scores and invasive breast cancer risk among women with a family history of breast cancer.Am J Clin Nutr. 2019 May 1;109(5):1393-1401. doi: 10.1093/ajcn/nqy392. Am J Clin Nutr. 2019. PMID: 30968114 Free PMC article.
-
Diet Quality Scores Inversely Associated with Postmenopausal Breast Cancer Risk Are Not Associated with Premenopausal Breast Cancer Risk in the California Teachers Study.J Nutr. 2018 Nov 1;148(11):1830-1837. doi: 10.1093/jn/nxy187. J Nutr. 2018. PMID: 30247577
-
Associations between Diet Quality Scores and Risk of Postmenopausal Estrogen Receptor-Negative Breast Cancer: A Systematic Review.J Nutr. 2018 Jan 1;148(1):100-108. doi: 10.1093/jn/nxx015. J Nutr. 2018. PMID: 29378048 Review.
-
Diet quality indices and postmenopausal breast cancer survival.Nutr Cancer. 2011;63(3):381-8. doi: 10.1080/01635581.2011.535963. Nutr Cancer. 2011. PMID: 21462090 Free PMC article.
Cited by
-
Adherence to Diet Quality Indices and Breast Cancer Risk in the Italian ORDET Cohort.Nutrients. 2024 Apr 17;16(8):1187. doi: 10.3390/nu16081187. Nutrients. 2024. PMID: 38674877 Free PMC article.
-
Healthy dietary patterns and risk of prostate cancer in men at high genetic risk.Int J Cancer. 2024 Jul 1;155(1):71-80. doi: 10.1002/ijc.34898. Epub 2024 Mar 1. Int J Cancer. 2024. PMID: 38429859
-
Causal relationship between dietary factors and breast cancer risk: A Mendelian randomization study.Heliyon. 2023 Oct 14;9(10):e20980. doi: 10.1016/j.heliyon.2023.e20980. eCollection 2023 Oct. Heliyon. 2023. PMID: 37867896 Free PMC article.
-
Higher Adherence to the AMED, DASH, and CHFP Dietary Patterns Is Associated with Better Cognition among Chinese Middle-Aged and Elderly Adults.Nutrients. 2023 Sep 14;15(18):3974. doi: 10.3390/nu15183974. Nutrients. 2023. PMID: 37764758 Free PMC article.
-
A Comparative Study of Healthy Dietary Patterns for Incident and Fatal Digestive System Cancer.Am J Gastroenterol. 2023 Nov 1;118(11):2061-2070. doi: 10.14309/ajg.0000000000002448. Epub 2023 Aug 7. Am J Gastroenterol. 2023. PMID: 37543749
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical