Newly born dentate granule neurons after pilocarpine-induced epilepsy have hilar basal dendrites with immature synapses
- PMID: 16480853
- DOI: 10.1016/j.eplepsyres.2005.12.003
Newly born dentate granule neurons after pilocarpine-induced epilepsy have hilar basal dendrites with immature synapses
Abstract
Neurogenesis in the subgranular zone of the dentate gyrus persists throughout the lifespan of mammals, and the resulting newly born neurons are incorporated into existing hippocampal circuitry. Seizures increase the rate of neurogenesis in the adult rodent brain and result in granule cells in the dentate gyrus with basal dendrites. Using doublecortin (DCX) immunocytochemistry to label newly generated neurons the current study focuses on the electron microscopic features of DCX-labeled cell bodies and dendritic processes in the dentate gyrus of rats with pilocarpine-induced epilepsy. At the base of the granule cell layer clusters of cells that include up to six DCX-labeled cell bodies were observed. The cell bodies in these clusters lacked a one-to-one association with an astrocyte cell body and its processes, a relationship that is typical for newly born granule cells in control rats. Also, DCX-labeled basal dendrites in the hilus had immature synapses while those in control rats lacked synapses. These results indicate that increased neurogenesis after seizures alters the one-to-one relationship between astrocytes and DCX-labeled newly generated neurons at the base of the granule cell layer. The data also suggest that the synapses on DCX-labeled hilar basal dendrites contribute to the persistence of hilar basal dendrites on neurons born after pilocarpine-induced seizures.
Similar articles
-
Structural changes for adult-born dentate granule cells after status epilepticus.Epilepsia. 2008 Jun;49 Suppl 5:13-8. doi: 10.1111/j.1528-1167.2008.01633.x. Epilepsia. 2008. PMID: 18522596 Review.
-
Newly generated granule cells show rapid neuroplastic changes in the adult rat dentate gyrus during the first five days following pilocarpine-induced seizures.Eur J Neurosci. 2007 Aug;26(3):583-92. doi: 10.1111/j.1460-9568.2007.05662.x. Eur J Neurosci. 2007. PMID: 17686039
-
Extranuclear estrogen receptor beta immunoreactivity is on doublecortin-containing cells in the adult and neonatal rat dentate gyrus.Brain Res. 2006 Nov 22;1121(1):46-58. doi: 10.1016/j.brainres.2006.08.084. Epub 2006 Oct 5. Brain Res. 2006. PMID: 17026970
-
Newly generated dentate granule cells from epileptic rats exhibit elongated hilar basal dendrites that align along GFAP-immunolabeled processes.Neuroscience. 2005;136(3):823-31. doi: 10.1016/j.neuroscience.2005.03.059. Neuroscience. 2005. PMID: 16344154
-
Integration of newly born dentate granule cells into adult brains: hypotheses based on normal and epileptic rodents.Brain Res Brain Res Rev. 2005 Feb;48(1):43-56. doi: 10.1016/j.brainresrev.2004.08.003. Brain Res Brain Res Rev. 2005. PMID: 15708627 Review.
Cited by
-
Epidemiology, Risk Factors, and Biomarkers of Post-Traumatic Epilepsy: A Comprehensive Overview.Biomedicines. 2024 Feb 9;12(2):410. doi: 10.3390/biomedicines12020410. Biomedicines. 2024. PMID: 38398011 Free PMC article. Review.
-
Antagonism of Macrophage Migration Inhibitory Factory (MIF) after Traumatic Brain Injury Ameliorates Astrocytosis and Peripheral Lymphocyte Activation and Expansion.Int J Mol Sci. 2020 Oct 9;21(20):7448. doi: 10.3390/ijms21207448. Int J Mol Sci. 2020. PMID: 33050322 Free PMC article.
-
Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy.Int J Mol Sci. 2020 Oct 3;21(19):7309. doi: 10.3390/ijms21197309. Int J Mol Sci. 2020. PMID: 33022963 Free PMC article. Review.
-
Neuroinflammatory mechanisms of post-traumatic epilepsy.J Neuroinflammation. 2020 Jun 17;17(1):193. doi: 10.1186/s12974-020-01854-w. J Neuroinflammation. 2020. PMID: 32552898 Free PMC article. Review.
-
Adult Neurogenesis in Epileptogenesis: An Update for Preclinical Finding and Potential Clinical Translation.Curr Neuropharmacol. 2020;18(6):464-484. doi: 10.2174/1570159X17666191118142314. Curr Neuropharmacol. 2020. PMID: 31744451 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources