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Review
. 2006 Jul;13(7):715-21.
doi: 10.1128/CVI.00052-06.

Defective virus drives human immunodeficiency virus infection, persistence, and pathogenesis

Diana Finzi  1 , Susan F Plaeger, Carl W Dieffenbach
Affiliations
Review

Defective virus drives human immunodeficiency virus infection, persistence, and pathogenesis

Diana Finzi et al. Clin Vaccine Immunol. 2006 Jul.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Resting CD4 T cells must be activated to produce virus. (a) HIV is most likely to infect a resting CD4 T cell. (b) Resting CD4 T cells are not permissive to HIV replication, and the PIC degrades in the cytoplasm of resting CD4 T cells. (c) Activation of the resting cell is necessary for viral replication to occur. (d) An uninfected resting cell that becomes activated can be productively infected regardless of its antigenic specificity. (e) Rarely, activated infected cells survive and become long-lived memory cells with integrated, latent provirus. (f) Reactivation of these cells also makes them permissive to HIV replication.
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