Long-term motor cortex plasticity induced by an electronic neural implant
- PMID: 17057705
- DOI: 10.1038/nature05226
Long-term motor cortex plasticity induced by an electronic neural implant
Abstract
It has been proposed that the efficacy of neuronal connections is strengthened when there is a persistent causal relationship between presynaptic and postsynaptic activity. Such activity-dependent plasticity may underlie the reorganization of cortical representations during learning, although direct in vivo evidence is lacking. Here we show that stable reorganization of motor output can be induced by an artificial connection between two sites in the motor cortex of freely behaving primates. An autonomously operating electronic implant used action potentials recorded on one electrode to trigger electrical stimuli delivered at another location. Over one or more days of continuous operation, the output evoked from the recording site shifted to resemble the output from the corresponding stimulation site, in a manner consistent with the potentiation of synaptic connections between the artificially synchronized populations of neurons. Changes persisted in some cases for more than one week, whereas the output from sites not incorporated in the connection was unaffected. This method for inducing functional reorganization in vivo by using physiologically derived stimulus trains may have practical application in neurorehabilitation after injury.
Comment in
-
Neurobiology: crossed circuits.Nature. 2006 Nov 2;444(7115):47-8. doi: 10.1038/444047a. Nature. 2006. PMID: 17080079 No abstract available.
Similar articles
-
Motor cortex reorganization across the lifespan.J Commun Disord. 2010 Jul-Aug;43(4):286-94. doi: 10.1016/j.jcomdis.2010.04.005. Epub 2010 Apr 8. J Commun Disord. 2010. PMID: 20478572 Review.
-
Associative motor cortex plasticity: direct evidence in humans.Cereb Cortex. 2009 Oct;19(10):2326-30. doi: 10.1093/cercor/bhn255. Epub 2009 Jan 28. Cereb Cortex. 2009. PMID: 19176639
-
In search of the motor engram: motor map plasticity as a mechanism for encoding motor experience.Neuroscientist. 2005 Oct;11(5):471-83. doi: 10.1177/1073858405278015. Neuroscientist. 2005. PMID: 16151047 Review.
-
Skilled-learning-induced potentiation in rat sensorimotor cortex: a transient form of behavioural long-term potentiation.Neuroscience. 2004;125(2):329-36. doi: 10.1016/j.neuroscience.2004.01.048. Neuroscience. 2004. PMID: 15062976
-
Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex.Neurobiol Learn Mem. 2002 Jan;77(1):63-77. doi: 10.1006/nlme.2000.4004. Neurobiol Learn Mem. 2002. PMID: 11749086
Cited by
-
Mu-Suppression Neurofeedback Training Targeting the Mirror Neuron System: A Pilot Study.Appl Psychophysiol Biofeedback. 2024 May 13. doi: 10.1007/s10484-024-09643-4. Online ahead of print. Appl Psychophysiol Biofeedback. 2024. PMID: 38739182
-
NSF DARE-Transforming modeling in neurorehabilitation: Four threads for catalyzing progress.J Neuroeng Rehabil. 2024 Apr 3;21(1):46. doi: 10.1186/s12984-024-01324-x. J Neuroeng Rehabil. 2024. PMID: 38570842 Free PMC article. Review.
-
Personalized strategies of neurostimulation: from static biomarkers to dynamic closed-loop assessment of neural function.Front Neurosci. 2024 Mar 7;18:1363128. doi: 10.3389/fnins.2024.1363128. eCollection 2024. Front Neurosci. 2024. PMID: 38516316 Free PMC article. Review.
-
The evolution of neuromodulation for chronic stroke: From neuroplasticity mechanisms to brain-computer interfaces.Neurotherapeutics. 2024 Apr;21(3):e00337. doi: 10.1016/j.neurot.2024.e00337. Epub 2024 Feb 19. Neurotherapeutics. 2024. PMID: 38377638 Free PMC article. Review.
-
Closed-loop experiments and brain machine interfaces with multiphoton microscopy.Neurophotonics. 2024 Jul;11(3):033405. doi: 10.1117/1.NPh.11.3.033405. Epub 2024 Feb 19. Neurophotonics. 2024. PMID: 38375331 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources