Laminar fate of cortical GABAergic interneurons is dependent on both birthdate and phenotype
- PMID: 17245711
- DOI: 10.1002/cne.21250
Laminar fate of cortical GABAergic interneurons is dependent on both birthdate and phenotype
Abstract
Pioneering work indicates that the final position of neurons in specific layers of the mammalian cerebral cortex is determined primarily by birthdate. Glutamatergic projection neurons are born in the cortical proliferative zones of the dorsal telencephalon, and follow an "inside-out" neurogenesis gradient: later-born cohorts migrate radially past earlier-born neurons to populate more superficial layers. GABAergic interneurons, the major source of cortical inhibition, comprise a heterogeneous population and are produced in proliferative zones of the ventral telencephalon. Mechanisms by which interneuron subclasses find appropriate layer-specific cortical addresses remain largely unexplored. Major cortical interneuron subclasses can be identified based on expression of distinct calcium-binding proteins including parvalbumin, calretinin, or calbindin. We determined whether cortical layer-patterning of interneurons is dependent on phenotype. Parvalbumin-positive interneurons populate cortical layers with an inside-out gradient, and birthdate is isochronous to projection neurons in the same layers. In contrast, another major GABAergic subtype, labeled using calretinin, populates the cerebral cortex using an opposite "outside-in" gradient, heterochronous to neighboring neurons. In addition to birthdate, phenotype is also a determinant of cortical patterning. Discovery of a cortical subpopulation that does not follow the well-established inside-out gradient has important implications for mechanisms of layer formation in the cerebral cortex.
2007 Wiley-Liss, Inc.
Similar articles
-
Secreted factors from ventral telencephalon induce the differentiation of GABAergic neurons in cortical cultures.Eur J Neurosci. 2006 Dec;24(11):2967-77. doi: 10.1111/j.1460-9568.2006.05194.x. Eur J Neurosci. 2006. PMID: 17156358
-
Irreversible loss of a subpopulation of cortical interneurons in the absence of glutamatergic network activity.Eur J Neurosci. 2004 Jun;19(11):2931-43. doi: 10.1111/j.0953-816X.2004.03403.x. Eur J Neurosci. 2004. PMID: 15182300
-
CXCR4 is required for proper regional and laminar distribution of cortical somatostatin-, calretinin-, and neuropeptide Y-expressing GABAergic interneurons.Cereb Cortex. 2010 Dec;20(12):2810-7. doi: 10.1093/cercor/bhq027. Epub 2010 Mar 3. Cereb Cortex. 2010. PMID: 20200107
-
Control of tangential/non-radial migration of neurons in the developing cerebral cortex.Neurochem Int. 2007 Jul-Sep;51(2-4):121-31. doi: 10.1016/j.neuint.2007.05.006. Epub 2007 May 21. Neurochem Int. 2007. PMID: 17588709 Review.
-
The origin and specification of cortical interneurons.Nat Rev Neurosci. 2006 Sep;7(9):687-96. doi: 10.1038/nrn1954. Epub 2006 Aug 2. Nat Rev Neurosci. 2006. PMID: 16883309 Review.
Cited by
-
Comparison of genes involved in brain development: insights into the organization and evolution of the telencephalic pallium.Sci Rep. 2024 Mar 13;14(1):6102. doi: 10.1038/s41598-024-51964-1. Sci Rep. 2024. PMID: 38480729 Free PMC article.
-
Long-term effects of low prenatal alcohol exposure on GABAergic interneurons of the murine posterior parietal cortex.Alcohol Clin Exp Res (Hoboken). 2023 Dec;47(12):2248-2261. doi: 10.1111/acer.15210. Epub 2023 Oct 27. Alcohol Clin Exp Res (Hoboken). 2023. PMID: 38151788
-
Origin, Development, and Synaptogenesis of Cortical Interneurons.Front Neurosci. 2022 Jun 27;16:929469. doi: 10.3389/fnins.2022.929469. eCollection 2022. Front Neurosci. 2022. PMID: 35833090 Free PMC article. Review.
-
Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.Sci Adv. 2022 May 6;8(18):eabm2545. doi: 10.1126/sciadv.abm2545. Epub 2022 May 6. Sci Adv. 2022. PMID: 35544642 Free PMC article.
-
Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders.Nat Rev Neurosci. 2022 May;23(5):275-286. doi: 10.1038/s41583-022-00572-x. Epub 2022 Mar 23. Nat Rev Neurosci. 2022. PMID: 35322263 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous