GABA: an excitatory transmitter in early postnatal life
- PMID: 1726341
- DOI: 10.1016/0166-2236(91)90003-d
GABA: an excitatory transmitter in early postnatal life
Abstract
In the adult mammalian CNS, GABA is the main inhibitory transmitter. It inhibits neuronal firing by increasing a Cl- conductance. Bicuculline blocks this effect and induces interictal discharges. A different picture is present in neonatal hippocampal neurones, where synaptically released or exogenously applied GABA depolarizes and excites neuronal membranes--an effect that is due to a different Cl- gradient. In fact, during the early neonatal period, GABA acting on GABAA receptors provides most of the excitatory drive, whereas excitatory glutamatergic synapses are quiescent. It is suggested that during development GABA exerts mainly a trophic action through membrane depolarization and a rise in intracellular Ca2+.
Similar articles
-
GABA is the principal fast-acting excitatory transmitter in the neonatal brain.Adv Neurol. 1999;79:189-201. Adv Neurol. 1999. PMID: 10514814 Review.
-
GABAB receptor-mediated inhibition of GABAA receptor calcium elevations in developing hypothalamic neurons.J Neurophysiol. 1998 Mar;79(3):1360-70. doi: 10.1152/jn.1998.79.3.1360. J Neurophysiol. 1998. PMID: 9497417
-
Changes in intracellular Ca2+ induced by GABAA receptor activation and reduction in Cl- gradient in neonatal rat neocortex.J Neurophysiol. 1998 Jan;79(1):439-46. doi: 10.1152/jn.1998.79.1.439. J Neurophysiol. 1998. PMID: 9425212
-
gamma-Aminobutyric acid (GABA): a fast excitatory transmitter which may regulate the development of hippocampal neurones in early postnatal life.Prog Brain Res. 1994;102:261-73. doi: 10.1016/S0079-6123(08)60545-2. Prog Brain Res. 1994. PMID: 7800817 Review.
-
A physiological role for GABAB receptors in the central nervous system.Nature. 1988 Mar 10;332(6160):156-8. doi: 10.1038/332156a0. Nature. 1988. PMID: 2831457
Cited by
-
The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives.Mol Autism. 2024 May 7;15(1):19. doi: 10.1186/s13229-024-00598-1. Mol Autism. 2024. PMID: 38711098 Free PMC article.
-
Bidirectional Regulation of GABAA Reversal Potential in the Adult Brain: Physiological and Pathological Implications.Life (Basel). 2024 Jan 19;14(1):143. doi: 10.3390/life14010143. Life (Basel). 2024. PMID: 38276272 Free PMC article. Review.
-
Serine 937 phosphorylation enhances KCC2 activity and strengthens synaptic inhibition.Sci Rep. 2023 Dec 8;13(1):21660. doi: 10.1038/s41598-023-48884-x. Sci Rep. 2023. PMID: 38066086 Free PMC article.
-
New Views of the DNA Repair Protein Ataxia-Telangiectasia Mutated in Central Neurons: Contribution in Synaptic Dysfunctions of Neurodevelopmental and Neurodegenerative Diseases.Cells. 2023 Aug 30;12(17):2181. doi: 10.3390/cells12172181. Cells. 2023. PMID: 37681912 Free PMC article. Review.
-
Leg Cycling Leads to Improvement of Spasticity by Enhancement of Presynaptic Inhibition in Patients with Cerebral Palsy.Phys Ther Res. 2023;26(2):65-70. doi: 10.1298/ptr.E10228. Epub 2023 Jun 20. Phys Ther Res. 2023. PMID: 37621569 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous