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. 2007 Aug 1;222(3):374-80.
doi: 10.1016/j.taap.2006.12.014. Epub 2006 Dec 22.

Thio-dimethylarsinate is a common metabolite in urine samples from arsenic-exposed women in Bangladesh

Reingard Raml  1 , Alice Rumpler, Walter Goessler, Marie Vahter, Li Li, Takafumi Ochi, Kevin A Francesconi
Affiliations

Thio-dimethylarsinate is a common metabolite in urine samples from arsenic-exposed women in Bangladesh

Reingard Raml et al. Toxicol Appl Pharmacol. .

Abstract

Over the last 6 years, much work on arsenic species in urine samples has been directed toward the determination of the reduced dimethylated arsenic species, DMA(III), because of its high toxicity and perceived key role in the metabolism of inorganic arsenic. Recent work, however, has suggested that DMA(III) may at times have been misidentified because its chromatographic properties can be similar to those of thio-dimethylarsinate (thio-DMA). We analyzed by HPLC-ICPMS (inductively coupled plasma mass spectrometry) urine samples from 75 arsenic-exposed women from Bangladesh with total arsenic concentrations ranging from 8 to 1034 microg As/L and found that thio-DMA was present in 44% of the samples at concentrations ranging mostly from trace amounts to 24 microg As/L (one sample contained 123 microg As/L). Cytotoxicity testing with HepG2 cells derived from human hepatocarcinoma indicated that thio-DMA was about 10-fold more cytotoxic than dimethylarsinate (DMA). The widespread occurrence of thio-DMA in urine from these arsenic-exposed women suggests that this arsenical may also be present in other urine samples and has so far escaped detection. The work highlights the need for analytical methods providing specific determinations of arsenic compounds in future studies on arsenic metabolism and toxicology.

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