Comment
doi: 10.1016/j.cmet.2007.12.002.
Fluxing the mitochondria to insulin resistance
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- PMID: 18177719
- DOI: 10.1016/j.cmet.2007.12.002
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Comment
Fluxing the mitochondria to insulin resistance
Cell Metab.
2008 Jan.
Free article
Abstract
Elevated fatty acids promote inflammation and insulin resistance. In this issue of Cell Metabolism, Koves et al. (2008) explore a novel paradigm suggesting that beta-oxidation of fatty acids exceeding the capacity of the tricarboxylic acid cycle yields incomplete fat oxidation and mitochondrial distress, obligatory events in the pathogenesis of insulin resistance.
Comment on
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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.Cell Metab. 2008 Jan;7(1):45-56. doi: 10.1016/j.cmet.2007.10.013. Cell Metab. 2008. PMID: 18177724
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