A prototypic matricellular protein in the tumor microenvironment--where there's SPARC, there's fire
- PMID: 18253934
- DOI: 10.1002/jcb.21688
A prototypic matricellular protein in the tumor microenvironment--where there's SPARC, there's fire
Abstract
Within the tumor microenvironment is a dynamic exchange between cancer cells and their surrounding stroma. This complex biologic system requires carefully designed models to understand the role of its stromal components in carcinogenesis, tumor progression, invasion, and metastasis. Secreted protein acidic and rich in cysteine (SPARC) is a prototypic matricellular protein at the center of this exchange. Two decades of basic science research combined with recent whole genome analyses indicate that SPARC is an important player in vertebrate evolution, normal development, and maintenance of normal tissue homeostasis. Therefore, SPARC might also play an important role in the tumor microenvironment. Clinical evidence indicates that SPARC expression correlates with tumor progression, but tightly controlled animal models have shown that the role of SPARC in tumor progression is dependent on tissue and tumor cell type. In this Prospectus, we review the current understanding of SPARC in the tumor microenvironment and discuss current and future investigations of SPARC and tumor-stromal interactions that require careful consideration of growth factors, cytokines, proteinases, and angiotropic factors that might influence SPARC activity and tumor progression.
Similar articles
-
SPARC in cancer biology: its role in cancer progression and potential for therapy.Drug Resist Updat. 2008 Dec;11(6):231-46. doi: 10.1016/j.drup.2008.08.005. Epub 2008 Oct 11. Drug Resist Updat. 2008. PMID: 18849185 Review.
-
SPARC enhances tumor stroma formation and prevents fibroblast activation.Oncogene. 2007 Jul 5;26(31):4513-22. doi: 10.1038/sj.onc.1210247. Epub 2007 Jan 29. Oncogene. 2007. PMID: 17260013
-
The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host.Cancer Metastasis Rev. 2008 Sep;27(3):523-37. doi: 10.1007/s10555-008-9135-x. Cancer Metastasis Rev. 2008. PMID: 18459035 Review.
-
Immunohistochemical expression of SPARC is correlated with recurrence, survival and malignant potential in meningiomas.APMIS. 2009 Sep;117(9):651-9. doi: 10.1111/j.1600-0463.2009.02516.x. APMIS. 2009. PMID: 19703125
-
SPARC and tumor growth: where the seed meets the soil?J Cell Biochem. 2004 Jul 1;92(4):679-90. doi: 10.1002/jcb.20091. J Cell Biochem. 2004. PMID: 15211566 Review.
Cited by
-
Immunohistochemical expression of SPARC in odontogenic keratocysts: a comparative study with other odontogenic cysts.BMC Oral Health. 2024 Feb 12;24(1):223. doi: 10.1186/s12903-024-03978-4. BMC Oral Health. 2024. PMID: 38347494 Free PMC article.
-
CYR61 promotes colorectal carcinoma progression via activating epithelial-mesenchymal transition.Am J Cancer Res. 2023 Oct 15;13(10):4872-4887. eCollection 2023. Am J Cancer Res. 2023. PMID: 37970355 Free PMC article.
-
Adaptive and non-adaptive gene expression responses in prostate cancer during androgen deprivation.PLoS One. 2023 Feb 21;18(2):e0281645. doi: 10.1371/journal.pone.0281645. eCollection 2023. PLoS One. 2023. PMID: 36809527 Free PMC article.
-
Cell Competition Shapes Metastatic Latency and Relapse.Cancer Discov. 2023 Jan 9;13(1):85-97. doi: 10.1158/2159-8290.CD-22-0236. Cancer Discov. 2023. PMID: 36098678 Free PMC article.
-
Plasma Protein Biomarkers Associated with Higher Ovarian Cancer Risk in BRCA1/2 Carriers.Cancers (Basel). 2021 May 11;13(10):2300. doi: 10.3390/cancers13102300. Cancers (Basel). 2021. PMID: 34064977 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous