Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's disease
- PMID: 18362099
- PMCID: PMC2367697
- DOI: 10.1093/brain/awn047
Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's disease
Abstract
Frontotemporal lobar degeneration (FTLD) often overlaps clinically with corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP), both of which have prominent eye movement abnormalities. To investigate the ability of oculomotor performance to differentiate between FTLD, Alzheimer's disease, CBS and PSP, saccades and smooth pursuit were measured in three FTLD subtypes, including 24 individuals with frontotemporal dementia (FTD), 19 with semantic dementia (SD) and six with progressive non-fluent aphasia (PA), as compared to 28 individuals with Alzheimer's disease, 15 with CBS, 10 with PSP and 27 control subjects. Different combinations of oculomotor abnormalities were identified in all clinical syndromes except for SD, which had oculomotor performance that was indistinguishable from age-matched controls. Only PSP patients displayed abnormalities in saccade velocity, whereas abnormalities in saccade gain were observed in PSP > CBS > Alzheimer's disease subjects. All patient groups except those with SD were impaired on the anti-saccade task, however only the FTLD subjects and not Alzheimer's disease, CBS or PSP groups, were able to spontaneously self-correct anti-saccade errors as well as controls. Receiver operating characteristic statistics demonstrated that oculomotor findings were superior to neuropsychological tests in differentiating PSP from other disorders, and comparable to neuropsychological tests in differentiating the other patient groups. These data suggest that oculomotor assessment may aid in the diagnosis of FTLD and related disorders.
Figures
![Fig. 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2638231/bin/awn047f1.gif)
![Fig. 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2638231/bin/awn047f2.gif)
![Fig. 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2638231/bin/awn047f3.gif)
![Fig. 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2638231/bin/awn047f4.gif)
![Fig. 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2638231/bin/awn047f5.gif)
![Fig. 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2638231/bin/awn047f6.gif)
Similar articles
-
Intracortical diffusion tensor imaging signature of microstructural changes in frontotemporal lobar degeneration.Alzheimers Res Ther. 2021 Oct 22;13(1):180. doi: 10.1186/s13195-021-00914-4. Alzheimers Res Ther. 2021. PMID: 34686217 Free PMC article.
-
Atypical parkinsonian syndromes: a general neurologist's perspective.Eur J Neurol. 2018 Jan;25(1):41-58. doi: 10.1111/ene.13412. Epub 2017 Sep 28. Eur J Neurol. 2018. PMID: 28803444 Free PMC article. Review.
-
Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy.Brain. 2015 Jul;138(Pt 7):1976-91. doi: 10.1093/brain/awv103. Epub 2015 Apr 19. Brain. 2015. PMID: 25895507 Free PMC article.
-
Saccade abnormalities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer disease.Arch Neurol. 2012 Apr;69(4):509-17. doi: 10.1001/archneurol.2011.1021. Arch Neurol. 2012. PMID: 22491196 Free PMC article.
-
Are frontotemporal lobar degeneration, progressive supranuclear palsy and corticobasal degeneration distinct diseases?Nat Clin Pract Neurol. 2006 Dec;2(12):658-65. doi: 10.1038/ncpneuro0357. Nat Clin Pract Neurol. 2006. PMID: 17117169 Review.
Cited by
-
Application and progress of advanced eye movement examinations in cognitive impairment.Front Aging Neurosci. 2024 Apr 17;16:1377406. doi: 10.3389/fnagi.2024.1377406. eCollection 2024. Front Aging Neurosci. 2024. PMID: 38694260 Free PMC article. Review.
-
Detecting Abnormal Eye Movements in Patients with Neurodegenerative Diseases - Current Insights.Eye Brain. 2024 Apr 9;16:3-16. doi: 10.2147/EB.S384769. eCollection 2024. Eye Brain. 2024. PMID: 38617403 Free PMC article. Review.
-
Differential eye movement features between Alzheimer's disease patients with and without depressive symptoms.Aging Clin Exp Res. 2023 Dec;35(12):2987-2996. doi: 10.1007/s40520-023-02595-5. Epub 2023 Nov 1. Aging Clin Exp Res. 2023. PMID: 37910289
-
Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management.Chem Rev. 2023 Oct 11;123(19):11488-11558. doi: 10.1021/acs.chemrev.3c00290. Epub 2023 Sep 25. Chem Rev. 2023. PMID: 37748126 Free PMC article. Review.
-
The application of saccades to assess cognitive impairment among older adults: a systematic review and meta-analysis.Aging Clin Exp Res. 2023 Nov;35(11):2307-2321. doi: 10.1007/s40520-023-02546-0. Epub 2023 Sep 7. Aging Clin Exp Res. 2023. PMID: 37676429
References
-
- Abel LA, Unverzagt F, Yee RD. Effects of stimulus predictability and interstimulus gap on saccades in Alzheimer's disease. Dement Geriatr Cogn Disord. 2002;13:235–43. - PubMed
-
- Beery KE. The Visual-Motor Integration Test: administration, scoring, and teaching Manual. Austin, TX: Pro-Ed; 1997.
-
- Boeve BF, Lang AE, Litvan I. Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia. Ann Neurol. 2003;54(Suppl 5):S15–9. - PubMed
-
- Boeve BF, Maraganore DM, Parisi JE, Ahlskog JE, Graff-Radford N, Caselli RJ, et al. Pathologic heterogeneity in clinically diagnosed corticobasal degeneration. Neurology. 1999;53:795–800. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous