microRNAs and cancer: an overview
- PMID: 18719380
- DOI: 10.4161/cc.7.16.6453
microRNAs and cancer: an overview
Abstract
MicroRNAs (miRNAs) are a recently discovered class of small RNA molecules that negatively regulate gene expression at the post-transcriptional level. MiRNAs play key roles in development and establishment of cell identity and aberrant metabolism/expression of miRNAs has been linked to human diseases including cancer. Components of the miRNA machinery and miRNAs themselves are involved in many cellular processes that are altered in cancer, such as differentiation, proliferation and apoptosis. Some miRNAs exhibit differential expression levels in cancer and have demonstrated capability to affect cellular transformation, carcinogenesis and metastasis acting either as oncogenes or tumour suppressors. We are only beginning to comprehend the functional repercussions of the gain or loss of particular microRNAs on cancer. Nonetheless, although microRNAs have been discovered in humans a mere eight years ago, a host of promising potential applications in the diagnosis, prognoses and therapy of cancer are emerging at a rapid pace.
Similar articles
-
OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma.Nature. 2010 Sep 2;467(7311):86-90. doi: 10.1038/nature09284. Epub 2010 Aug 8. Nature. 2010. PMID: 20693987
-
[MicroRNAs and cancer-associated signal transduction pathways].Yi Chuan. 2007 Dec;29(12):1419-28. Yi Chuan. 2007. PMID: 18065374 Review. Chinese.
-
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.Eur J Cancer. 2011 May;47(8):1127-37. doi: 10.1016/j.ejca.2011.02.008. Epub 2011 Mar 12. Eur J Cancer. 2011. PMID: 21402473 Review.
-
MicroRNAs and human cancer.Exp Oncol. 2012;34(1):2-8. Exp Oncol. 2012. PMID: 22453141 Review.
-
The role of extracellular vesicle microRNAs in cancer biology.Clin Chem Lab Med. 2017 May 1;55(5):648-656. doi: 10.1515/cclm-2016-0708. Clin Chem Lab Med. 2017. PMID: 28231055 Review.
Cited by
-
Domestic Animal Models of Central Nervous System Tumors: Focus on Meningiomas.Life (Basel). 2023 Nov 30;13(12):2284. doi: 10.3390/life13122284. Life (Basel). 2023. PMID: 38137885 Free PMC article. Review.
-
Molecular Biomarkers of Bladder Cancer: A Mini-Review.Physiol Res. 2023 Oct 27;72(S3):S247-S256. doi: 10.33549/physiolres.935187. Physiol Res. 2023. PMID: 37888968 Free PMC article. Review.
-
miR-100 rs1834306 a > G polymorphism decreases neuroblastoma risk in Chinese children.Cancer Rep (Hoboken). 2023 Oct;6(10):e1875. doi: 10.1002/cnr2.1875. Epub 2023 Jul 28. Cancer Rep (Hoboken). 2023. PMID: 37503828 Free PMC article.
-
Unlocking the Potential of Circulating miRNAs in the Breast Cancer Neoadjuvant Setting: A Systematic Review and Meta-Analysis.Cancers (Basel). 2023 Jun 30;15(13):3424. doi: 10.3390/cancers15133424. Cancers (Basel). 2023. PMID: 37444533 Free PMC article. Review.
-
MicroRNA-155 and Disease-Related Immunohistochemical Parameters in Cutaneous Melanoma.Diagnostics (Basel). 2023 Mar 22;13(6):1205. doi: 10.3390/diagnostics13061205. Diagnostics (Basel). 2023. PMID: 36980512 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources