Clinical Trial
doi: 10.1056/NEJMoa0808949.
Functional brown adipose tissue in healthy adults
Affiliations
- PMID: 19357407
- DOI: 10.1056/NEJMoa0808949
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Clinical Trial
Functional brown adipose tissue in healthy adults
N Engl J Med.
.
Free article
Erratum in
- N Engl J Med. 2009 Sep 10;361(11):1123
Abstract
Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
2009 Massachusetts Medical Society
Comment in
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Brown adipose tissue--when it pays to be inefficient.N Engl J Med. 2009 Apr 9;360(15):1553-6. doi: 10.1056/NEJMe0900466. N Engl J Med. 2009. PMID: 19357412 Free PMC article. No abstract available.
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The importance of brown adipose tissue.N Engl J Med. 2009 Jul 23;361(4):415-6; author reply 418-21. doi: 10.1056/NEJMc091009. N Engl J Med. 2009. PMID: 19625723 No abstract available.
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The importance of brown adipose tissue.N Engl J Med. 2009 Jul 23;361(4):416-7; author reply 418-21. N Engl J Med. 2009. PMID: 19630141 No abstract available.
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The importance of brown adipose tissue.N Engl J Med. 2009 Jul 23;361(4):417; author reply 418-21. N Engl J Med. 2009. PMID: 19630143 No abstract available.
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