Enabling a systems biology approach to immunology: focus on innate immunity
- PMID: 19428301
- DOI: 10.1016/j.it.2009.03.009
Enabling a systems biology approach to immunology: focus on innate immunity
Abstract
Immunity is not simply the product of a series of discrete linear signalling pathways; rather it is comprised of a complex set of integrated responses arising from a dynamic network of thousands of molecules subject to multiple influences. Its behaviour often cannot be explained or predicted solely by examining its components. Here, we review recently developed resources for the systems-level investigation of immunity. Although innate immunity is emphasized here, its considerable overlap with adaptive immunity makes many of these resources relevant to both arms of the immune response. We discuss recent studies implementing these approaches and illustrate the potential of systems biology to generate novel insights into the complexities of innate immunity.
Similar articles
-
Mass spectrometry in systems biology: an overview.Mass Spectrom Rev. 2008 Nov-Dec;27(6):635-60. doi: 10.1002/mas.20182. Mass Spectrom Rev. 2008. PMID: 18636545 Review.
-
How can ontologies help vector biology?Trends Parasitol. 2008 Jun;24(6):249-52. doi: 10.1016/j.pt.2008.03.002. Epub 2008 Apr 24. Trends Parasitol. 2008. PMID: 18440275
-
Systems biology in human health and disease.Mol Syst Biol. 2007;3:136. doi: 10.1038/msb4100175. Epub 2007 Sep 25. Mol Syst Biol. 2007. PMID: 17893698 Free PMC article. No abstract available.
-
A systems biology analysis of the Drosophila phagosome.Nature. 2007 Jan 4;445(7123):95-101. doi: 10.1038/nature05380. Epub 2006 Dec 6. Nature. 2007. PMID: 17151602
-
Resources for integrative systems biology: from data through databases to networks and dynamic system models.Brief Bioinform. 2006 Dec;7(4):318-30. doi: 10.1093/bib/bbl036. Epub 2006 Oct 13. Brief Bioinform. 2006. PMID: 17040977 Review.
Cited by
-
Analysis of Persian Bioinformatics Research with Topic Modeling.Biomed Res Int. 2023 Apr 17;2023:3728131. doi: 10.1155/2023/3728131. eCollection 2023. Biomed Res Int. 2023. PMID: 37101687 Free PMC article.
-
A transcriptomic analysis of the effects of macrophage polarization and endotoxin tolerance on the response to Salmonella.PLoS One. 2022 Oct 14;17(10):e0276010. doi: 10.1371/journal.pone.0276010. eCollection 2022. PLoS One. 2022. PMID: 36240188 Free PMC article.
-
Mesenchymal Stem Cell-Derived Antimicrobial Peptides as Potential Anti-Neoplastic Agents: New Insight into Anticancer Mechanisms of Stem Cells and Exosomes.Front Cell Dev Biol. 2022 Jul 6;10:900418. doi: 10.3389/fcell.2022.900418. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35874827 Free PMC article. Review.
-
Recent trends in next generation immunoinformatics harnessed for universal coronavirus vaccine design.Pathog Glob Health. 2023 Mar;117(2):134-151. doi: 10.1080/20477724.2022.2072456. Epub 2022 May 12. Pathog Glob Health. 2023. PMID: 35550001 Free PMC article. Review.
-
Effects of cannabis oil extract on immune response gene expression in human small airway epithelial cells (HSAEpC): implications for chronic obstructive pulmonary disease (COPD).J Cannabis Res. 2020 Jan 31;2(1):5. doi: 10.1186/s42238-019-0014-9. J Cannabis Res. 2020. PMID: 33526116 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
