Review
doi: 10.1016/j.toxlet.2009.03.017.
Epub 2009 Mar 31.
Current understanding of the mechanisms involved in metabolic detoxification of warfare nerve agents
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- PMID: 19433263
- DOI: 10.1016/j.toxlet.2009.03.017
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Review
Current understanding of the mechanisms involved in metabolic detoxification of warfare nerve agents
Toxicol Lett.
.
Abstract
This study reviews current understanding of chemical, biochemical and toxicological aspects and mechanisms of metabolism of warfare nerve agents. Among enzymes participating in metabolism of nerve agents the role of A-esterases, serum cholinesterase and carboxylesterases is discussed. This article also discusses other aspects of metabolism of the agents such as protein binding and the role of tissue depots for these compounds.
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