The efficacy of diffusion-weighted imaging for the detection of colorectal cancer
- PMID: 19453043
The efficacy of diffusion-weighted imaging for the detection of colorectal cancer
Abstract
Background/aims: Diffusion-weighted imaging (DWI) is a new magnetic resonance (MR) imaging technique that evaluates the diffusion of water molecules. Its clinical usefulness in the acute stage of cerebral infraction has been established. Recent technical developments have enabled DWI for human body and the usefulness of DWI for detecting malignant tumors such as liver, kidney, ovary, and breast tumors has been reported. This study documents cases of colorectal cancer detected by DWI and discusses the efficacy of DWI for the evaluation of colorectal cancer.
Methodology: DWI, computed tomography (CT) and colonoscopy examinations were performed on 18 patients with colorectal cancer. MRI examinations were performed using a 1.5-T imager (Toshiba, Otawara, Japan). The signal intensity was measured in a series of DWI and the apparent diffusion coefficient (ADC) values were calculated in order to differentiate the cancers from normal tissues. Two experienced radiologists evaluated the depth of tumor invasion into the colorectal wall (tumor staging), the involvement of regional lymph nodes (nodal staging), and the presence or absence of metastasis (metastatic staging) on DWI and CT images according to the TNM classification system. TNM staging of each tumor was compared with the pathologic and surgical findings.
Results: There were no differences between the DWI and the CT images regarding their abilities to detect early colorectal cancer. However, DWI could detect advanced colorectal cancer and liver metastasis more sensitivity, or accurately than CT with no enhancing material. In one patient who did not undergo a surgical resection, a follow up DWI showed peritoneal seeding and bone metastasis.
Conclusion: Although DWI has a difficulty to detect early colorectal cancer, DWI has the potential to be clinically effective for the evaluation of preoperative TNM staging and the postoperative follow-up of colorectal cancer.
Similar articles
-
Interest of diffusion-weighted echo-planar MR imaging and apparent diffusion coefficient mapping in gynecological malignancies: a review.J Magn Reson Imaging. 2011 May;33(5):1020-7. doi: 10.1002/jmri.22546. J Magn Reson Imaging. 2011. PMID: 21509857 Review.
-
The efficacy of diffusion-weighted imaging for the detection and evaluation of acute pancreatitis.Hepatogastroenterology. 2009 Sep-Oct;56(94-95):1407-10. Hepatogastroenterology. 2009. PMID: 19950800
-
The usefulness of diffusion-weighted imaging (DWI) for the detection of gastric cancer.Hepatogastroenterology. 2007 Jul-Aug;54(77):1378-81. Hepatogastroenterology. 2007. PMID: 17708258
-
Diffusion-weighted single shot echo planar imaging of colorectal cancer using a sensitivity-encoding technique.Jpn J Clin Oncol. 2004 Oct;34(10):620-6. doi: 10.1093/jjco/hyh108. Jpn J Clin Oncol. 2004. PMID: 15591461
-
Diagnostic imaging in cancer.Prim Care. 1992 Dec;19(4):677-713. Prim Care. 1992. PMID: 1465483 Review.
Cited by
-
Endorectal Ultrasound and Magnetic Resonance Imaging for Rectal Cancer Staging: A Modern Multimodality Approach.J Clin Med. 2021 Feb 8;10(4):641. doi: 10.3390/jcm10040641. J Clin Med. 2021. PMID: 33567516 Free PMC article.
-
Lesion detection performance of an abbreviated gadoxetic acid-enhanced MRI protocol for colorectal liver metastasis surveillance.Eur Radiol. 2019 Nov;29(11):5852-5860. doi: 10.1007/s00330-019-06113-y. Epub 2019 Mar 19. Eur Radiol. 2019. PMID: 30888485
-
Diffusion-weighted imaging in rectal cancer: current applications and future perspectives.Br J Radiol. 2019 Apr;92(1096):20180655. doi: 10.1259/bjr.20180655. Epub 2019 Mar 5. Br J Radiol. 2019. PMID: 30433814 Free PMC article. Review.
-
Is neoadjuvant chemotherapy necessary for patients with initially resectable colorectal liver metastases in the era of effective chemotherapy?Korean J Hepatobiliary Pancreat Surg. 2011 Nov;15(4):206-17. doi: 10.14701/kjhbps.2011.15.4.206. Epub 2011 Dec 15. Korean J Hepatobiliary Pancreat Surg. 2011. PMID: 26421041 Free PMC article.
-
Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma.Diagn Interv Radiol. 2014 Mar-Apr;20(2):105-9. doi: 10.5152/dir.2013.13275. Diagn Interv Radiol. 2014. PMID: 24100063 Free PMC article.