CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
- PMID: 19633658
- DOI: 10.1038/nm.1964
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
Abstract
Inflammation is increasingly regarded as a key process underlying metabolic diseases in obese individuals. In particular, obese adipose tissue shows features characteristic of active local inflammation. At present, however, little is known about the sequence of events that comprises the inflammatory cascade or the mechanism by which inflammation develops. We found that large numbers of CD8(+) effector T cells infiltrated obese epididymal adipose tissue in mice fed a high-fat diet, whereas the numbers of CD4(+) helper and regulatory T cells were diminished. The infiltration by CD8(+) T cells preceded the accumulation of macrophages, and immunological and genetic depletion of CD8(+) T cells lowered macrophage infiltration and adipose tissue inflammation and ameliorated systemic insulin resistance. Conversely, adoptive transfer of CD8(+) T cells to CD8-deficient mice aggravated adipose inflammation. Coculture and other in vitro experiments revealed a vicious cycle of interactions between CD8(+) T cells, macrophages and adipose tissue. Our findings suggest that obese adipose tissue activates CD8(+) T cells, which, in turn, promote the recruitment and activation of macrophages in this tissue. These results support the notion that CD8(+) T cells have an essential role in the initiation and propagation of adipose inflammation.
Comment in
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T-ing up inflammation in fat.Nat Med. 2009 Aug;15(8):846-7. doi: 10.1038/nm0809-846. Nat Med. 2009. PMID: 19661987 No abstract available.
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CD8+ T cells drive adipose tissue inflammation--a novel clue for NASH pathogenesis?J Hepatol. 2010 Jan;52(1):130-2. doi: 10.1016/j.jhep.2009.10.019. Epub 2009 Oct 29. J Hepatol. 2010. PMID: 19914729 No abstract available.
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