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Comparative Study
. 2009 Oct;66(4):505-12.
doi: 10.1002/ana.21742.

Periodontitis and incidence of cerebrovascular disease in men

Monik Jimenez  1 , Elizabeth A Krall, Raul I Garcia, Pantel S Vokonas, Thomas Dietrich
Affiliations
Comparative Study

Periodontitis and incidence of cerebrovascular disease in men

Monik Jimenez et al. Ann Neurol. 2009 Oct.

Abstract

Objective: To identify associations between periodontitis and incidence of cerebrovascular disease.

Methods: We analyzed data of 1,137 dentate men in the Veterans Affairs Normative Aging and Dental Longitudinal Study who were followed with triennial medical/dental exams for up to 34 years (mean, 24 years). We evaluated incidence of cerebrovascular events consistent with stroke or transient ischemic attack in relation to mean radiographic alveolar bone loss (a measure of periodontitis history) and cumulative periodontal probing depth (a measure of current periodontal inflammation). Cox proportional hazards models were fit controlling for age, baseline socioeconomic status, and time-varying effects of established cardiovascular risk factors.

Results: Eighty incident cases of cerebrovascular disease occurred from 27,506 person-years. Periodontal bone loss was significantly associated with an increased hazard rate (HR) of cerebrovascular disease (HR, 3.52; 95% confidence interval [CI], 1.59-7.81 comparing highest to lowest bone loss category; p for trend, <0.001). There was a stronger effect among men aged <65 years (HR, 5.81; 95% CI, 1.63-20.7) as compared with men aged > or =65 years (HR, 2.39; 95% CI, 0.91-6.25). Periodontal probing depth was not associated with a significantly increased rate of cerebrovascular disease in the combined or age-stratified analyses.

Interpretation: These results support an association between history of periodontitis-but not current periodontal inflammation-and incidence of cerebrovascular disease in men, independent of established cardiovascular risk factors, particularly among men aged <65 years.

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Conflict of interest statement

Conflict of Interests: All authors declare that they have no conflicts of interest and therefore have nothing to declare.

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References

    1. Dietrich T, Jimenez M, Krall Kaye EA, et al. Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation. 2008 Apr 1;117(13):1668–1674. - PMC - PubMed
    1. Beck J, Garcia R, Heiss G, et al. Periodontal disease and cardiovascular disease. J Periodontol. 1996 Oct;67(10 Suppl):1123–1137. - PubMed
    1. Joshipura KJ, Hung HC, Rimm EB, et al. Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke. 2003 Jan;34(1):47–52. - PubMed
    1. Grau AJ, Becher H, Ziegler CM, et al. Periodontal disease as a risk factor for ischemic stroke. Stroke. 2004 Feb;35(2):496–501. - PubMed
    1. Wu T, Trevisan M, Genco RJ, et al. Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow-up study. Arch Intern Med. 2000 Oct 9;160(18):2749–2755. - PubMed

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