Comment
doi: 10.18632/aging.100094.
Awakening p53 in senescent cells using nutlin-3
Affiliations
- PMID: 20157556
- PMCID: PMC2815727
- DOI: 10.18632/aging.100094
Item in Clipboard
Comment
Awakening p53 in senescent cells using nutlin-3
Aging (Albany NY).
.
No abstract available
Keywords: Senescence; nutlin-3; p53; tumor suppression.
Figures
(A) The
MDM2 inhibitor nutln-3 increases p53-mediated senescence, apoptosis, and
cell cycle arrest. (B) The SIRT1 small-molecule inhibitor Tenovin 6
works in tandem with nutlin-3 to induce apoptosis or permanent senescence
in cancer cells.
Comment on
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Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3.Aging (Albany NY). 2009 Sep 25;1(10):845-54. doi: 10.18632/aging.100091. Aging (Albany NY). 2009. PMID: 20157557 Free PMC article.
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