Capsaicinoids in the hottest pepper Bhut Jolokia and its antioxidant and antiinflammatory activities
- PMID: 20184029
Capsaicinoids in the hottest pepper Bhut Jolokia and its antioxidant and antiinflammatory activities
Abstract
Hot peppers are known for medicinally important capsaicinoids. Bhut Jolokia, Capsicum chinense/Capsicum frutescens, is the hottest pepper in the world. However, its bioactivity and quantity of heat principles are not reported. We have now quantified capsaicin (C) and dihydrocapsaicin (DHC) in Bhut Jolokia and compared it with commonly consumed hot peppers, Jalapeno (Capsicum annuum) and Scotch Bonnet (Capsicum chinense). The concentration of C and DHC in Bhut Jolokia was 5.36%, which is about 338 and 18 times greater than in Scotch Bonnet and Jalapeno, respectively. We have also isolated capsaicin (C) and dihydrocapsaicin (DHC) in pure form and determined lipid peroxidation (LPO) and cyclooxygenase (COX-1 and -2) enzymes inhibitory concentrations. This is the first report of the quantification of C and DHC in Bhut Jolokia, comparison of capsaicinoids content in Bhut Jolokia with Jalapeno and Scotch Bonnet hot peppers and the COX and LPO inhibitory activities of C and DHC.
Similar articles
-
Comparative Analysis of Fruit Metabolites and Pungency Candidate Genes Expression between Bhut Jolokia and Other Capsicum Species.PLoS One. 2016 Dec 9;11(12):e0167791. doi: 10.1371/journal.pone.0167791. eCollection 2016. PLoS One. 2016. PMID: 27936081 Free PMC article.
-
Variability in capsaicinoid content and Scoville heat ratings of commercially grown Jalapeño, Habanero and Bhut Jolokia peppers.Food Chem. 2016 Nov 1;210:606-12. doi: 10.1016/j.foodchem.2016.04.135. Epub 2016 Apr 30. Food Chem. 2016. PMID: 27211688
-
Naga chilli: a potential source of capsaicinoids with broad-spectrum ethnopharmacological applications.J Ethnopharmacol. 2010 Oct 28;132(1):1-14. doi: 10.1016/j.jep.2010.08.034. Epub 2010 Aug 20. J Ethnopharmacol. 2010. PMID: 20728519 Review.
-
Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin.Int J Toxicol. 2007;26 Suppl 1:3-106. doi: 10.1080/10915810601163939. Int J Toxicol. 2007. PMID: 17365137 Review.
-
Screening Capsicum accessions for capsaicinoids content.J Environ Sci Health B. 2006;41(5):717-29. doi: 10.1080/03601230600701908. J Environ Sci Health B. 2006. PMID: 16785178
Cited by
-
Genetic characterization of a locus responsible for low pungency using EMS-induced mutants in Capsicum annuum L.Theor Appl Genet. 2024 Apr 12;137(5):101. doi: 10.1007/s00122-024-04602-3. Theor Appl Genet. 2024. PMID: 38607449 Free PMC article.
-
Single-cell RNA sequencing reveals the effects of capsaicin in the treatment of sepsis-induced liver injury.MedComm (2020). 2023 Oct 5;4(5):e395. doi: 10.1002/mco2.395. eCollection 2023 Oct. MedComm (2020). 2023. PMID: 37808269 Free PMC article.
-
Preparation and Characterization of Capsaicin Encapsulated Polymeric Micelles and Studies of Synergism with Nicotinic Acids as Potential Anticancer Nanomedicines.J Pharm Bioallied Sci. 2023 Jul-Sep;15(3):107-125. doi: 10.4103/jpbs.jpbs_311_22. Epub 2023 Jul 28. J Pharm Bioallied Sci. 2023. PMID: 37705853 Free PMC article.
-
The Genus Capsicum: A Review of Bioactive Properties of Its Polyphenolic and Capsaicinoid Composition.Molecules. 2023 May 22;28(10):4239. doi: 10.3390/molecules28104239. Molecules. 2023. PMID: 37241977 Free PMC article. Review.
-
Capsicum baccatum Red Pepper Prevents Cardiometabolic Risk in Rats Fed with an Ultra-Processed Diet.Metabolites. 2023 Mar 5;13(3):385. doi: 10.3390/metabo13030385. Metabolites. 2023. PMID: 36984825 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Medical