PGC-1 coactivators in cardiac development and disease
- PMID: 20884884
- PMCID: PMC2955978
- DOI: 10.1161/CIRCRESAHA.110.223818
PGC-1 coactivators in cardiac development and disease
Abstract
The beating heart requires a constant flux of ATP to maintain contractile function, and there is increasing evidence that energetic defects contribute to the development of heart failure. The last 10 years have seen a resurgent interest in cardiac intermediary metabolism and a dramatic increase in our understanding of transcriptional networks that regulate cardiac energetics. The PPAR-γ coactivator (PGC)-1 family of proteins plays a central role in these pathways. The mechanisms by which PGC-1 proteins regulate transcriptional networks and are regulated by physiological cues, as well as the roles they play in cardiac development and disease, are reviewed here.
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