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. 2010 Nov;83(5):1166-9.
doi: 10.4269/ajtmh.2010.09-0480.

Serological investigations of flavivirus prevalence in Khammouane Province, Lao People's Democratic Republic, 2007-2008

Alexandra Hiscox  1 , Christian H Winter, Phengta Vongphrachanh, Thongchanh Sisouk, Virasack Somoulay, Samlane Phompida, Surinder Kaul, Pany Sananikhom, Thi Yen Nguyen, Richard E Paul, Paul Brey, Juliet E Bryant
Affiliations

Serological investigations of flavivirus prevalence in Khammouane Province, Lao People's Democratic Republic, 2007-2008

Alexandra Hiscox et al. Am J Trop Med Hyg. 2010 Nov.

Abstract

A large-scale cross-sectional seroprevalence study of dengue (DEN) and Japanese encephalitis (JE) was conducted in Khammouane province, Lao PDR, as part of the initial baseline health impact assessment of the Nam Theun 2 hydroelectric dam construction project. Health surveys were performed between May 2007 and February 2008 with serum samples collected from healthy individuals involved in the resettlement program of 16 villages (total surveyed population 4,369). Hemagglutination inhibition assay using flavivirus antigens (DENV1, DENV3, and JEV) performed on 1,708 plasma specimens revealed 30.4% (519) cross-reactive positives, and 10% (172) and 1.3% (22) positives to JEV or DENV, respectively. Entomological surveys conducted during the rainy season of 2008 indicated the presence of competent flavivirus vectors (Culex vishnui group and Aedes albopictus), although Aedes aegypti was not found. Continued surveillance and investigation is warranted to assess the clinical disease burden of flaviviruses in this area that is undergoing rapid ecological and demographic change.

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Figures

Figure 1.
Figure 1.
Map of Nam Theun reservoir showing locations of original villages before inundation (red) and resettlement areas (black).
Figure 2.
Figure 2.
Seroprevalence of anti-flavivirus antibodies of different age groups, including 95% confidence interval (N = sample size per age group).
Figure 3.
Figure 3.
Seroprevalence (mean and 95% confidence interval) of anti-flavivirus antibodies of 10 different villages. KHK, Old SopHia Phonetong; NBK, NongBouakham; NKN, NakaiNeua; NKT, NakaiTai; NN, Namnian; ODS, Oudomsouk; PPP, Phonphanpaek; SH, SopHia, SP, SopPhene; TL, Thalang.
See this image and copyright information in PMC

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