Risk factors associated with encapsulating peritoneal sclerosis in Dutch EPS study
- PMID: 21454391
- DOI: 10.3747/pdi.2010.00167
Risk factors associated with encapsulating peritoneal sclerosis in Dutch EPS study
Abstract
Objective: Encapsulating peritoneal sclerosis (EPS) is a serious complication of peritoneal dialysis (PD) with a multifactorial pathophysiology and possible increasing incidence. The aim of the present study was to evaluate the independent associations of PD duration, age, dialysis fluids, and kidney transplantation with EPS.
Methods: A multicenter case-control study was performed in the Netherlands from 1 January 1996 until 1 July 2007. The population comprised 63 patients with EPS and 126 control patients. Control patients were selected from the national registry and were matched for date of PD start. Associations were analyzed using a log linear regression model. Primary outcome was appearance of EPS.
Results: Compared with control patients, patients with EPS were younger at the start of PD (34.7 ± 15.4 years vs. 51.5 ± 14.7 years, p < 0.0001). The cumulative period on PD was longer in EPS patients than in control patients (78.7 ± 37.8 months vs. 32.8 ± 24 months, p < 0.0001), and the cumulative period on icodextrin was also longer in EPS patients (32.7 ± 23.3 months vs. 18.1 ± 15.7 months, p = 0.006). Compared with control patients, more EPS patients underwent kidney transplantation (47 vs. 59, p < 0.0001). With regard to the period after transplantation, the yearly probability of EPS increased in the year after transplantation to 7.5% from 1.75%. In multivariate regression analysis, cumulative PD duration, age at PD start, transplantation, time from last transplantation to EPS, calendar time, time on icodextrin, and ultrafiltration failure were independently associated with EPS. Transfer from PD to hemodialysis for reasons other than suspected EPS could not be identified as a risk factor for EPS.
Conclusions: Duration of PD, age at PD start, kidney transplantation, time since last transplantation, ultrafiltration failure, and time on icodextrin were associated with a higher risk of EPS.
Similar articles
-
Risk factors of severe peritoneal sclerosis in chronic peritoneal dialysis patients.Ren Fail. 2017 Nov;39(1):32-39. doi: 10.1080/0886022X.2016.1244075. Epub 2016 Oct 24. Ren Fail. 2017. PMID: 27774831 Free PMC article.
-
Encapsulating Peritoneal Sclerosis in Peritoneal Dialysis Patients After Kidney Transplantation.Transplant Proc. 2018 Jan-Feb;50(1):160-164. doi: 10.1016/j.transproceed.2017.12.054. Transplant Proc. 2018. PMID: 29407302
-
Significant Decreasing Incidence of Encapsulating Peritoneal Sclerosis in the Dutch Population of Peritoneal Dialysis Patients.Perit Dial Int. 2017 Mar-Apr;37(2):230-234. doi: 10.3747/pdi.2016.00109. Perit Dial Int. 2017. PMID: 28360369
-
Posttransplant encapsulating peritoneal sclerosis: presentation of cases and review of the literature.J Nephrol. 2013 Sep-Oct;26(5):906-11. doi: 10.5301/jn.5000230. Epub 2012 Oct 11. J Nephrol. 2013. PMID: 23065918 Review.
-
Encapsulating peritoneal sclerosis: a single-center experience and review of the literature.Int Urol Nephrol. 2011 Jun;43(2):519-26. doi: 10.1007/s11255-010-9848-y. Epub 2010 Oct 6. Int Urol Nephrol. 2011. PMID: 20924672 Review.
Cited by
-
Renal hyperparathyroidism- a risk factor in the development of encapsulating peritoneal sclerosis.Front Endocrinol (Lausanne). 2024 Mar 19;15:1282925. doi: 10.3389/fendo.2024.1282925. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38567303 Free PMC article.
-
Risk factors for Encapsulating Peritoneal Sclerosis in patients undergoing peritoneal dialysis: A meta-analysis.PLoS One. 2022 Mar 21;17(3):e0265584. doi: 10.1371/journal.pone.0265584. eCollection 2022. PLoS One. 2022. PMID: 35312717 Free PMC article. Review.
-
Reprogramming of Mesothelial-Mesenchymal Transition in Chronic Peritoneal Diseases by Estrogen Receptor Modulation and TGF-β1 Inhibition.Int J Mol Sci. 2020 Jun 10;21(11):4158. doi: 10.3390/ijms21114158. Int J Mol Sci. 2020. PMID: 32532126 Free PMC article. Review.
-
Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death.Nephrol Dial Transplant. 2019 Sep 1;34(9):1585-1591. doi: 10.1093/ndt/gfz034. Nephrol Dial Transplant. 2019. PMID: 30820552 Free PMC article.
-
Effects of long-term treatment with low-GDP, pH-neutral solutions on peritoneal membranes in peritoneal dialysis patients.Clin Exp Nephrol. 2019 May;23(5):689-699. doi: 10.1007/s10157-018-1679-7. Epub 2018 Dec 13. Clin Exp Nephrol. 2019. PMID: 30547267
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources