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. 2011 Apr 21;16(4):3433-43.
doi: 10.3390/molecules16043433.

Antioxidant, total phenolic content and cytotoxicity evaluation of selected Malaysian plants

Suhailah Wasman Qader  1 , Mahmood Ameen Abdulla, Lee Suan Chua, Nigar Najim, Mazatulikhma Mat Zain, Salehhuddin Hamdan
Affiliations

Antioxidant, total phenolic content and cytotoxicity evaluation of selected Malaysian plants

Suhailah Wasman Qader et al. Molecules. .

Abstract

Aqueous and ethanol extracts of different traditional Malaysian plants (Polygonum minus, Andrographis paniculata, Curcuma xanthorrhiza, Momordica charantia and Strobilanthes crispus) were evaluated for their antioxidant properties, total phenolic content and cytotoxic activity. Antioxidant activity was evaluated by using 1,1-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. The results showed that ethanol extracts contain high antioxidant activities compared to aqueous extracts. The findings exhibited a strong correlation between antioxidant activity and the total phenol contents. In addition, all the plant extracts showed non-toxic effects against a normal human lung fibroblast cell line (Hs888Lu). Although traditionally aqueous extracts are used, we determined that ethanol extracts usually achieved better activity in the assays.

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Figures

Figure 1
Figure 1
Correlation between TPC and DPPH scavenging percentage.
Figure 2
Figure 2
Correlation between total phenolic content and FRAP reducing power.
Figure 3
Figure 3
Cytotoxic activity of five Malaysian plants in normal lung (Hs888Lu) cell line at concentration of 500 µg/mL and 24 hr exposure time.
See this image and copyright information in PMC

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