Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examination
- PMID: 21600760
- PMCID: PMC3175366
- DOI: 10.1016/j.ejca.2011.04.019
Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examination
Abstract
Background: Sunitinib is a standard treatment for metastatic renal cell carcinoma. Angiotensin system inhibitors, including angiotensin converting enzyme inhibitors and angiotensin II receptor blockers, are widely used in hypertension, kidney disease and heart failure. Data suggests that they may inhibit tumourigenesis.
Aims: To study the effect of angiotensin system inhibitors on sunitinib treatment outcome in metastatic renal cell carcinoma.
Methods: We performed a retrospective study of an unselected cohort of patients with metastatic renal cell carcinoma who were treated with sunitinib. Patients were divided into angiotensin system inhibitors users (group 1) and non-users (group 2). The effect of angiotensin system inhibitors on objective response, time to disease progression and overall survival, was tested with adjustment for known confounding risk factors through logistic regression model and Cox regression model.
Results: Between 2004 and 2010, 127 patients with metastatic renal cell carcinoma were treated with sunitinib, 44 group 1 and 83 group 2. The groups were balanced regarding known clinicopathologic prognostic factors. Objective response was partial response/stable disease 86% versus 72% and progressive disease 14% versus 28% (p=0.07) in group 1 versus 2, respectively. Median progression free survival was 13 versus 6 months (HR 0.537, p=0.0055), and median overall survival 30 versus 23 months (HR 0.688, p=0.21), in favour of group 1.
Conclusions: Angiotensin system inhibitors may improve the outcome of sunitinib treatment in metastatic renal cell carcinoma. This should be investigated prospectively, and if validated applied in clinical practise and clinical trials.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Conflict of interest statement
None declared.
Figures
Similar articles
-
Hypertension and angiotensin system inhibitors: impact on outcome in sunitinib-treated patients for metastatic renal cell carcinoma.Ann Oncol. 2015 Jun;26(6):1128-1133. doi: 10.1093/annonc/mdv147. Epub 2015 Mar 20. Ann Oncol. 2015. PMID: 25795198
-
Outcome of Patients With Metastatic Chromophobe Renal Cell Carcinoma Treated With Sunitinib.Oncologist. 2016 Oct;21(10):1212-1217. doi: 10.1634/theoncologist.2015-0428. Epub 2016 Jul 5. Oncologist. 2016. PMID: 27382030 Free PMC article.
-
[Comparison of efficacy between sorafenib and sunitinib as first-line therapy for metastatic renal cell carcinoma and analyze prognostic factors for survival].Zhonghua Zhong Liu Za Zhi. 2018 May 23;40(5):384-389. doi: 10.3760/cma.j.issn.0253-3766.2018.05.012. Zhonghua Zhong Liu Za Zhi. 2018. PMID: 29860767 Chinese.
-
Sunitinib (Sutent): a novel agent for the treatment of metastatic renal cell carcinoma.J Oncol Pharm Pract. 2007 Mar;13(1):5-15. doi: 10.1177/1078155207077924. J Oncol Pharm Pract. 2007. PMID: 17621562 Review.
-
Alternate sunitinib schedules in patients with metastatic renal cell carcinoma.Ann Oncol. 2015 Jul;26(7):1300-4. doi: 10.1093/annonc/mdv030. Epub 2015 Jan 26. Ann Oncol. 2015. PMID: 25628443 Free PMC article. Review.
Cited by
-
Correlation between Angiotensin Inhibitor Administration and Longer Survival in Patients Who Underwent Curative Resection for Pancreatic Cancer.Yonsei Med J. 2024 Jun;65(6):324-331. doi: 10.3349/ymj.2023.0399. Yonsei Med J. 2024. PMID: 38804026 Free PMC article.
-
Renin-Angiotensin Inhibitor, Captopril, Attenuates Growth of Patient-Derived Colorectal Liver Metastasis Organoids.Int J Mol Sci. 2024 Mar 14;25(6):3282. doi: 10.3390/ijms25063282. Int J Mol Sci. 2024. PMID: 38542253 Free PMC article.
-
The Expression of Alamandine Receptor MrgD in Clear Cell Renal Cell Carcinoma Is Associated with a Worse Prognosis and Unfavorable Response to Antiangiogenic Therapy.Int J Mol Sci. 2024 Jan 25;25(3):1499. doi: 10.3390/ijms25031499. Int J Mol Sci. 2024. PMID: 38338778 Free PMC article.
-
Angiotensin-converting enzyme inhibitors for ovarian cancer? - a new adjuvant option or a silent trap.Rep Pract Oncol Radiother. 2023 Aug 28;28(4):551-564. doi: 10.5603/RPOR.a2023.0059. eCollection 2023. Rep Pract Oncol Radiother. 2023. PMID: 37795232 Free PMC article. Review.
-
Repurposing of Chronically Used Drugs in Cancer Therapy: A Chance to Grasp.Cancers (Basel). 2023 Jun 15;15(12):3199. doi: 10.3390/cancers15123199. Cancers (Basel). 2023. PMID: 37370809 Free PMC article. Review.
References
-
- Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108. - PubMed
-
- Lam JS, Leppert JT, Belldegrun AS, Figlin RA. Novel approaches in the therapy of metastatic renal cell carcinoma. World J Urol. 2005;23:202–12. - PubMed
-
- Motzer RJ, Bander NH, Nanus DM. Renal-cell carcinoma. N Engl J Med. 1996;335:865–75. - PubMed
-
- Janzen NK, Kim HL, Figlin RA, Belldegrun AS. Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol Clin North Am. 2003;30:843–52. - PubMed
-
- Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. NEJM. 2007;356:115–24. - PubMed
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical