Induction of oligodendrocyte differentiation by activators of adenylate cyclase
- PMID: 2174977
- DOI: 10.1002/jnr.490270107
Induction of oligodendrocyte differentiation by activators of adenylate cyclase
Abstract
Oligodendrocyte differentiation is accelerated by analogs of cyclic AMP (cAMP), such as N6,2-'O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP) or 8-bromo cAMP, in developing rat glial cell cultures (Raible and McMorris, 1989). However, it is not known whether the immature developing oligodendrocytes have G protein-coupled adenylate cyclase capable of generating cAMP, as would be required if development of the cells is normally regulated by endogenous cAMP. In the present study, we demonstrate that the diterpene forskolin, a potent activator of adenylate cyclase, or cholera toxin, which activates adenylate cyclase through G protein modification, can induce a precocious increase in oligodendrocyte number. When both forskolin and cholera toxin are added together, oligodendrocyte differentiation is induced to a level similar to that observed in response to cAMP analogs. These results establish for the first time that modulation of the endogenous cAMP regulatory system alters the schedule of oligodendrocyte differentiation.
Similar articles
-
cAMP signaling in Mycobacterium tuberculosis.Indian J Exp Biol. 2009 Jun;47(6):393-400. Indian J Exp Biol. 2009. PMID: 19634702 Review.
-
Adenylyl cyclase-cAMP system inhibits thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.Mol Cell Endocrinol. 2005 Jan 14;229(1-2):75-82. doi: 10.1016/j.mce.2004.09.004. Mol Cell Endocrinol. 2005. PMID: 15607531
-
The adenylate cyclase receptor complex and aqueous humor formation.Yale J Biol Med. 1984 May-Jun;57(3):283-300. Yale J Biol Med. 1984. PMID: 6093393 Free PMC article. Review.
-
In vivo and in vitro models of demyelinating disease: activation of the adenylate cyclase system influences JHM virus expression in explanted rat oligodendrocytes.J Virol. 1987 Dec;61(12):3795-803. doi: 10.1128/JVI.61.12.3795-3803.1987. J Virol. 1987. PMID: 2824815 Free PMC article.
-
Glucagon-induced refractoriness of hepatocyte adenylate cyclase: comparison of homologous and heterologous components and evidence against a role of cAMP.Pharmacol Toxicol. 1989 May;64(5):397-403. doi: 10.1111/j.1600-0773.1989.tb00675.x. Pharmacol Toxicol. 1989. PMID: 2475864
Cited by
-
The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation.Acta Pharmacol Sin. 2024 Mar;45(3):490-501. doi: 10.1038/s41401-023-01183-7. Epub 2023 Nov 7. Acta Pharmacol Sin. 2024. PMID: 37935896
-
Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment.Nat Neurosci. 2022 Dec;25(12):1714-1723. doi: 10.1038/s41593-022-01197-0. Epub 2022 Nov 24. Nat Neurosci. 2022. PMID: 36424430 Free PMC article.
-
Oscillatory calcium release and sustained store-operated oscillatory calcium signaling prevents differentiation of human oligodendrocyte progenitor cells.Sci Rep. 2022 Apr 13;12(1):6160. doi: 10.1038/s41598-022-10095-1. Sci Rep. 2022. PMID: 35418597 Free PMC article.
-
The white matter is a pro-differentiative niche for glioblastoma.Nat Commun. 2021 Apr 12;12(1):2184. doi: 10.1038/s41467-021-22225-w. Nat Commun. 2021. PMID: 33846316 Free PMC article.
-
Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment.Front Immunol. 2019 Jul 24;10:1727. doi: 10.3389/fimmu.2019.01727. eCollection 2019. Front Immunol. 2019. PMID: 31396231 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
