Upstream dysfunction of somatomotor functional connectivity after corticospinal damage in stroke
- PMID: 21803932
- PMCID: PMC3822763
- DOI: 10.1177/1545968311411054
Upstream dysfunction of somatomotor functional connectivity after corticospinal damage in stroke
Abstract
Background: Recent studies have shown that focal injuries can have remote effects on network function that affect behavior, but these network-wide repercussions are poorly understood.
Objective: This study tested the hypothesis that lesions specifically to the outflow tract of a distributed network can result in upstream dysfunction in structurally intact portions of the network. In the somatomotor system, this upstream dysfunction hypothesis predicted that lesions of the corticospinal tract might be associated with functional disruption within the system. Motor impairment might then reflect the dual contribution of corticospinal damage and altered network functional connectivity.
Methods: A total of 23 subacute stroke patients and 13 healthy controls participated in the study. Corticospinal tract damage was quantified using a template of the tract generated from diffusion tensor imaging in healthy controls. Somatomotor network functional integrity was determined by resting state functional connectivity magnetic resonance imaging.
Results: The extent of corticospinal damage was negatively correlated with interhemispheric resting functional connectivity, in particular with connectivity between the left and right central sulcus. Although corticospinal damage accounted for much of the variance in motor performance, the behavioral impact of resting connectivity was greater in subjects with mild or moderate corticospinal damage and less in those with severe corticospinal damage.
Conclusions: Our results demonstrated that dysfunction of cortical functional connectivity can occur after interruption of corticospinal outflow tracts and can contribute to impaired motor performance. Recognition of these secondary effects from a focal lesion is essential for understanding brain-behavior relationships after injury, and they may have important implications for neurorehabilitation.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3822763/bin/nihms-504225-f0001.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3822763/bin/nihms-504225-f0002.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3822763/bin/nihms-504225-f0003.gif)
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3822763/bin/nihms-504225-f0004.gif)
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3822763/bin/nihms-504225-f0005.gif)
![Figure 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3822763/bin/nihms-504225-f0006.gif)
Similar articles
-
Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery.Neurorehabil Neural Repair. 2021 Nov;35(11):1010-1019. doi: 10.1177/15459683211041318. Epub 2021 Sep 21. Neurorehabil Neural Repair. 2021. PMID: 34546138 Free PMC article.
-
Enhanced interhemispheric functional connectivity compensates for anatomical connection damages in subcortical stroke.Stroke. 2015 Apr;46(4):1045-51. doi: 10.1161/STROKEAHA.114.007044. Epub 2015 Feb 26. Stroke. 2015. PMID: 25721013
-
Structural and resting-state brain connectivity of motor networks after stroke.Stroke. 2015 Jan;46(1):296-301. doi: 10.1161/STROKEAHA.114.006307. Epub 2014 Dec 4. Stroke. 2015. PMID: 25477218 Review. No abstract available.
-
Why use a connectivity-based approach to study stroke and recovery of function?Neuroimage. 2012 Oct 1;62(4):2271-80. doi: 10.1016/j.neuroimage.2012.02.070. Epub 2012 Mar 5. Neuroimage. 2012. PMID: 22414990 Free PMC article. Review.
-
Pyramidal tract lesions and movement-associated cortical recruitment in patients with MS.Neuroimage. 2004 Sep;23(1):141-7. doi: 10.1016/j.neuroimage.2004.05.005. Neuroimage. 2004. PMID: 15325360
Cited by
-
Spinal Cord Stimulation for Poststroke Hemiparesis: A Scoping Review.Am J Occup Ther. 2024 Mar 1;78(2):7802180220. doi: 10.5014/ajot.2024.050533. Am J Occup Ther. 2024. PMID: 38477681 Free PMC article. Review.
-
The locations of stroke lesions next to the posterior internal capsule may predict the recovery of the related proprioceptive deficits.Front Neurosci. 2023 Oct 3;17:1248975. doi: 10.3389/fnins.2023.1248975. eCollection 2023. Front Neurosci. 2023. PMID: 37854290 Free PMC article.
-
Functional network disorganization and cognitive decline following fractionated whole-brain radiation in mice.Geroscience. 2024 Feb;46(1):543-562. doi: 10.1007/s11357-023-00944-w. Epub 2023 Sep 25. Geroscience. 2024. PMID: 37749370 Free PMC article.
-
Secondary neurodegeneration following Stroke: what can blood biomarkers tell us?Front Neurol. 2023 Sep 1;14:1198216. doi: 10.3389/fneur.2023.1198216. eCollection 2023. Front Neurol. 2023. PMID: 37719764 Free PMC article. Review.
-
Neurophysiological characterization of stroke recovery: A longitudinal TMS and EEG study.CNS Neurosci Ther. 2024 Mar;30(3):e14471. doi: 10.1111/cns.14471. Epub 2023 Sep 18. CNS Neurosci Ther. 2024. PMID: 37718708 Free PMC article.
References
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical