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. 2011 Nov;124(11):1043-50.
doi: 10.1016/j.amjmed.2011.06.013.

Obesity is not protective against fracture in postmenopausal women: GLOW

Juliet E Compston  1 , Nelson B Watts, Roland Chapurlat, Cyrus Cooper, Steven Boonen, Susan Greenspan, Johannes Pfeilschifter, Stuart Silverman, Adolfo Díez-Pérez, Robert Lindsay, Kenneth G Saag, J Coen Netelenbos, Stephen Gehlbach, Frederick H Hooven, Julie Flahive, Jonathan D Adachi, Maurizio Rossini, Andrea Z Lacroix, Christian Roux, Philip N Sambrook, Ethel S Siris; Glow Investigators
Affiliations

Obesity is not protective against fracture in postmenopausal women: GLOW

Juliet E Compston et al. Am J Med. 2011 Nov.

Abstract

Objective: To investigate the prevalence and incidence of clinical fractures in obese, postmenopausal women enrolled in the Global Longitudinal study of Osteoporosis in Women (GLOW).

Methods: This was a multinational, prospective, observational, population-based study carried out by 723 physician practices at 17 sites in 10 countries. A total of 60,393 women aged ≥ 55 years were included. Data were collected using self-administered questionnaires that covered domains that included patient characteristics, fracture history, risk factors for fracture, and anti-osteoporosis medications.

Results: Body mass index (BMI) and fracture history were available at baseline and at 1 and 2 years in 44,534 women, 23.4% of whom were obese (BMI ≥ 30 kg/m(2)). Fracture prevalence in obese women at baseline was 222 per 1000 and incidence at 2 years was 61.7 per 1000, similar to rates in nonobese women (227 and 66.0 per 1000, respectively). Fractures in obese women accounted for 23% and 22% of all previous and incident fractures, respectively. The risk of incident ankle and upper leg fractures was significantly higher in obese than in nonobese women, while the risk of wrist fracture was significantly lower. Obese women with fracture were more likely to have experienced early menopause and to report 2 or more falls in the past year. Self-reported asthma, emphysema, and type 1 diabetes were all significantly more common in obese than nonobese women with incident fracture. At 2 years, 27% of obese women with incident fracture were receiving bone protective therapy, compared with 41% of nonobese and 57% of underweight women.

Conclusions: Our results demonstrate that obesity is not protective against fracture in postmenopausal women and is associated with increased risk of ankle and upper leg fractures.

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References

    1. Becker DJ, Kilgore ML, Morrisey MA. The societal burden of osteoporosis. Curr Rheumatol Rep. 2010;12:186–191. - PubMed
    1. Burge R, Dawson-Hughes B, Solomon DH, et al. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res. 2007;22:465–475. - PubMed
    1. Kanis JA, Johnell O. Requirements for DXA for the management of osteoporosis in Europe. Osteoporos Int. 2005;16:229–238. - PubMed
    1. Cooper C, Campion G, Melton LJ., 3rd Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992;2:285–289. - PubMed
    1. De Laet C, Kanis JA, Oden A, et al. Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int. 2005;16:1330–1338. - PubMed

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