Does anti-TNF therapy cause any change in platelet activation in ankylosing spondylitis patients? A comparative study
- PMID: 22173846
- DOI: 10.1007/s11239-011-0663-9
Does anti-TNF therapy cause any change in platelet activation in ankylosing spondylitis patients? A comparative study
Abstract
Recently, it has been reported that ankylosing spondylitis (AS) was characterised by endothelial dysfunction and the development of atherosclerotic complications. In this study, we evaluated platelet and endothelial activation parameters in AS patients. Fiftynine AS patients and 22 healthy controls were included. The clinical features and acute phase parameters were evaluated. In all patients and healthy controls, platelet-monocyte complexes (PMC), platelet-neutrophil complexes, basal and ADP-stimulated P-selectin (CD62P) expression were determined by flow cytometry; soluble E-selectin (sE-selectin) and soluble CD40L (sCD40L) were determined by ELISA. AS patients were divided into two groups as active and inactive by using BASDAI. In 15 AS patients, the evaluated parameters were assessed before and after 12 weeks of anti-TNF therapy. PMC and sCD40L levels in AS patients were significantly higher than in the control group (P values 0.013 and 0.016). The evaluated variables were similar in active and inactive AS groups (P > 0.05). There were no significant changes in platelet and endothelial activation parameters in AS patients after anti-TNF therapy (P > 0.05). Platelet activation which is reflected by high levels of PMC and sCD40L might be responsible for the increased frequency of atherosclerosis in AS. The platelet activation in our AS patients was not associated with disease activity and did not improve after anti-TNF therapy.
Similar articles
-
Elevated platelet-monocyte complexes in patients with psoriatic arthritis.Platelets. 2009 Nov;20(7):493-7. doi: 10.3109/09537100903165174. Platelets. 2009. PMID: 19852688
-
Increased platelet activation markers in rheumatoid arthritis: are they related with subclinical atherosclerosis?Platelets. 2008 Mar;19(2):146-54. doi: 10.1080/09537100701210057. Platelets. 2008. PMID: 17852775
-
Adalimumab, etanercept and infliximab for the treatment of ankylosing spondylitis: a systematic review and economic evaluation.Health Technol Assess. 2007 Aug;11(28):1-158, iii-iv. doi: 10.3310/hta11280. Health Technol Assess. 2007. PMID: 17651658 Review.
-
Increased circulating platelet-neutrophil, platelet-monocyte complexes, and platelet activation in patients with ulcerative colitis: a comparative study.Am J Hematol. 2006 Oct;81(10):753-9. doi: 10.1002/ajh.20655. Am J Hematol. 2006. PMID: 16941615
-
First update of the international ASAS consensus statement for the use of anti-TNF agents in patients with ankylosing spondylitis.Ann Rheum Dis. 2006 Mar;65(3):316-20. doi: 10.1136/ard.2005.040758. Epub 2005 Aug 11. Ann Rheum Dis. 2006. PMID: 16096329 Free PMC article.
Cited by
-
Crucial role of lncRNA NONHSAG037054.2 and GABPA, and their related functional networks, in ankylosing spondylitis.Exp Ther Med. 2024 Mar 27;27(5):237. doi: 10.3892/etm.2024.12525. eCollection 2024 May. Exp Ther Med. 2024. PMID: 38628657 Free PMC article.
-
Global Proteomic Analyses Reveals Abnormal Immune Regulation in Patients With New Onset Ankylosing Spondylitis.Front Immunol. 2022 Mar 17;13:838891. doi: 10.3389/fimmu.2022.838891. eCollection 2022. Front Immunol. 2022. PMID: 35371008 Free PMC article.
-
Associations of Platelet Count with Inflammation and Response to Anti-TNF-α Therapy in Patients with Ankylosing Spondylitis.Front Pharmacol. 2020 Nov 6;11:559593. doi: 10.3389/fphar.2020.559593. eCollection 2020. Front Pharmacol. 2020. PMID: 33343345 Free PMC article.
-
Endothelial dysfunction in patients with ankylosing spondylitis.Reumatologia. 2019;57(2):100-105. doi: 10.5114/reum.2019.84815. Epub 2019 Apr 29. Reumatologia. 2019. PMID: 31130748 Free PMC article. Review.
-
Anti-TNF-α therapy reduces endothelial cell activation in non-diabetic ankylosing spondylitis patients.Rheumatol Int. 2015 Dec;35(12):2069-78. doi: 10.1007/s00296-015-3314-1. Epub 2015 Jul 5. Rheumatol Int. 2015. PMID: 26143161
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials