Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan 18:9:23.
doi: 10.1186/1743-422X-9-23.

Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection

En-Qiang Chen  1 , Hui Sun, Ping Feng, Dao-Yin Gong, Cong Liu, Lang Bai, Wen-Bing Yang, Xue-Zhong Lei, Li-Yu Chen, Fei-Jun Huang, Hong Tang
Affiliations

Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection

En-Qiang Chen et al. Virol J. .

Abstract

Hepatocyte nuclear factors 4 alpha (HNF4α) and 3 beta (HNF3β) are members of a group of liver-enriched transcription factors (LETFs) that play important roles in regulating the replication of hepatitis B virus (HBV) and liver inflammation. However, the relationship of the level of HNF4α and HNF3β with the severity of HBV-infected liver diseases is unclear. In this study, liver tissue samples from different types of HBV patients were collected, and HNF4α and HNF3β expression were detected by immunohistochemistry. The expression of HNF4α was significant higher in patients with severe hepatitis B(SHB) than those with chronic hepatitis B(CHB) and liver cirrhosis(LC) (both P < 0.05), but similar between patients with CHB and LC (P > 0.05). And the expression of HNF3β was similar among patients with CHB, LC and SHB (P > 0.05 for all pairwise comparison). This suggests that the expression level of HNF4α was different in patients with different outcome of HBV infection, high expression level of HNF4α may correlate with occurrence of SHB.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The expression of HNF4α and HNF3βin liver tissue of typical patients in three groups were shown. The scores of HNF4α were higher in c1 as compared to a1 and b1; while the scores of HNF3 were similar among a2, b2 and c2.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat. 2004;11:97–107. doi: 10.1046/j.1365-2893.2003.00487.x. - DOI - PubMed
    1. Blum HE. Hepatitis B virus: significance of naturally occurring mutants. Intervirology. 1993;35:40–50. - PubMed
    1. Marcellin P, Pequignot F, Delarocque-Astagneau E, Zarski JP, Ganne N, Hillon P, Antona D, Bovet M, Mechain M, Asselah T, Desenclos JC, Jougla E. Mortality related to chronic hepatitis B and chronic hepatitis C in France: evidence for the role of HIV coinfection and alcohol consumption. J Hepatol. 2008;48:200–207. doi: 10.1016/j.jhep.2007.09.010. - DOI - PubMed
    1. Huang Y, Lok AS. Viral factors and outcomes of chronic HBV infection. Am J Gastroenterol. 2011;106:93–95. doi: 10.1038/ajg.2010.404. - DOI - PubMed
    1. Museru O, Franco-Paredes C. Epidemiology and clinical outcomes of hepatitis B virus infection among refugees seen at a U.S. travel medicine clinic: 2005-2008. Travel Med Infect Dis. 2009;7:171–174. doi: 10.1016/j.tmaid.2009.01.008. - DOI - PubMed

Publication types

Substances

-