Epigenetic impact of dietary polyphenols in cancer chemoprevention: lifelong remodeling of our epigenomes
- PMID: 22465217
- DOI: 10.1016/j.phrs.2012.03.007
Epigenetic impact of dietary polyphenols in cancer chemoprevention: lifelong remodeling of our epigenomes
Abstract
Cancer, as one of the non-communicable diseases, remains one of the leading causes of death around the world. Recently, epigenetic changes in DNA methylation patterns at CpG sites (epimutations) or deregulated chromatin states of tumor promoting genes and noncoding RNAs emerged as major governing factors in tumor progression and cancer drug sensitivity. Furthermore, various environmental factors such as nutrition, behavior, stress, and toxins remodel our epigenomes lifelong in a beneficial or detrimental way. Since epigenetic marks (epimutations) are reversible in contrast to genetic defects, chemopreventive nutritional polyphenols (soy, genistein, resveratrol, catechin, curcumin) are currently evaluated for their ability to reverse adverse epigenetic marks in cancer (stem) cells to attenuate tumorigenesis-progression, prevent metastasis or sensitize for drug sensitivity. Although polyphenols in fruit and vegetables may help to reduce the risk of cancer, few protective effects have been firmly established, presumably because of inappropriate timing or dosing of diet exposure or due to confounding factors such as smoking and alcohol. In this review will discuss the possible epigenetic contributions of dietary polyphenols in cancer chemoprevention.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Similar articles
-
Natural products in the reprogramming of cancer epigenetics.Toxicol Appl Pharmacol. 2021 Apr 15;417:115467. doi: 10.1016/j.taap.2021.115467. Epub 2021 Feb 22. Toxicol Appl Pharmacol. 2021. PMID: 33631231 Review.
-
Epigenetic diet: impact on the epigenome and cancer.Epigenomics. 2011 Aug;3(4):503-18. doi: 10.2217/epi.11.71. Epigenomics. 2011. PMID: 22022340 Free PMC article. Review.
-
Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome.Chem Res Toxicol. 2012 Jan 13;25(1):61-73. doi: 10.1021/tx200378c. Epub 2011 Oct 28. Chem Res Toxicol. 2012. PMID: 21992498 Review.
-
Cancer chemoprevention by targeting the epigenome.Curr Drug Targets. 2011 Dec;12(13):1925-56. doi: 10.2174/138945011798184155. Curr Drug Targets. 2011. PMID: 21158707 Review.
-
Cancer chemoprevention by dietary polyphenols: promising role for epigenetics.Biochem Pharmacol. 2010 Dec 15;80(12):1771-92. doi: 10.1016/j.bcp.2010.06.036. Epub 2010 Jun 26. Biochem Pharmacol. 2010. PMID: 20599773 Free PMC article. Review.
Cited by
-
Dietary Polyphenols against Oxidative Stress in Head and Neck Cancer: What's New, What's Next.J Cancer. 2024 Jan 1;15(2):293-308. doi: 10.7150/jca.90545. eCollection 2024. J Cancer. 2024. PMID: 38169656 Free PMC article. Review.
-
Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude.Commun Biol. 2023 Oct 2;6(1):1001. doi: 10.1038/s42003-023-05341-9. Commun Biol. 2023. PMID: 37783835 Free PMC article.
-
Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist.J Endocrinol Invest. 2024 Jan;47(1):17-33. doi: 10.1007/s40618-023-02169-2. Epub 2023 Sep 11. J Endocrinol Invest. 2024. PMID: 37697017 Free PMC article. Review.
-
Aging and chronic inflammation: highlights from a multidisciplinary workshop.Immun Ageing. 2023 Jun 8;20(1):25. doi: 10.1186/s12979-023-00352-w. Immun Ageing. 2023. PMID: 37291596 Free PMC article. Review.
-
Beyond Antioxidant Activity: Redox Properties of Catechins May Affect Changes in the DNA Methylation Profile-The Example of SRXN1 Gene.Antioxidants (Basel). 2023 Mar 20;12(3):754. doi: 10.3390/antiox12030754. Antioxidants (Basel). 2023. PMID: 36979004 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources