Collateral sensitivity as a strategy against cancer multidrug resistance
- PMID: 22483810
- PMCID: PMC3348266
- DOI: 10.1016/j.drup.2012.03.002
Collateral sensitivity as a strategy against cancer multidrug resistance
Abstract
While chemotherapy remains the most effective treatment for disseminated tumors, acquired or intrinsic drug resistance accounts for approximately 90% of treatment failure. Multidrug resistance (MDR), the simultaneous resistance to drugs that differ both structurally and mechanistically, often results from drug efflux pumps in the cell membrane that reduce intracellular drug levels to less than therapeutic concentrations. Expression of the MDR transporter P-glycoprotein (P-gp, MDR1, ABCB1) has been shown to correlate with overall poor chemotherapy response and prognosis. This review will focus on collateral sensitivity (CS), the ability of compounds to kill MDR cells selectively over the parental cells from which they were derived. Insights into CS may offer an alternative strategy for the clinical resolution of MDR, as highly selective and potent CS agents may lead to drugs that are effective at MDR cell killing and tumor resensitization. Four main mechanistic hypotheses for CS will be reviewed, followed by a discussion on quantitative and experimental evaluation of CS.
Published by Elsevier Ltd.
Figures
![Fig. 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3348266/bin/nihms-368937-f0001.gif)
![Fig. 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3348266/bin/nihms-368937-f0002.gif)
Similar articles
-
β-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function.Phytomedicine. 2016 Mar 15;23(3):316-23. doi: 10.1016/j.phymed.2016.01.008. Epub 2016 Feb 6. Phytomedicine. 2016. PMID: 26969385
-
Development of Fourth Generation ABC Inhibitors from Natural Products: A Novel Approach to Overcome Cancer Multidrug Resistance.Anticancer Agents Med Chem. 2015;15(5):605-15. doi: 10.2174/1871520615666150113103439. Anticancer Agents Med Chem. 2015. PMID: 25584696 Review.
-
The dynamics of drug resistance: a mathematical perspective.Drug Resist Updat. 2012 Feb-Apr;15(1-2):90-7. doi: 10.1016/j.drup.2012.01.003. Epub 2012 Mar 3. Drug Resist Updat. 2012. PMID: 22387162 Free PMC article. Review.
-
Relevance of multidrug resistance in the age of targeted therapy.Curr Opin Drug Discov Devel. 2009 Mar;12(2):246-52. Curr Opin Drug Discov Devel. 2009. PMID: 19333870 Review.
-
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.Cancer Res. 2008 Oct 1;68(19):7905-14. doi: 10.1158/0008-5472.CAN-08-0499. Cancer Res. 2008. PMID: 18829547 Free PMC article.
Cited by
-
Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells.RSC Med Chem. 2024 Feb 26;15(4):1348-1361. doi: 10.1039/d3md00711a. eCollection 2024 Apr 24. RSC Med Chem. 2024. PMID: 38665830 Free PMC article.
-
PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors.Nat Cancer. 2024 Jun;5(6):938-952. doi: 10.1038/s43018-024-00756-7. Epub 2024 Apr 18. Nat Cancer. 2024. PMID: 38637658
-
Treatment of evolving cancers will require dynamic decision support.Ann Oncol. 2023 Oct;34(10):867-884. doi: 10.1016/j.annonc.2023.08.008. Ann Oncol. 2023. PMID: 37777307 Free PMC article. Review.
-
Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters.Nat Rev Cancer. 2023 Nov;23(11):762-779. doi: 10.1038/s41568-023-00612-3. Epub 2023 Sep 15. Nat Rev Cancer. 2023. PMID: 37714963 Review.
-
Fighting Multidrug Resistance with Ruthenium-Cyclopentadienyl Compounds: Unveiling the Mechanism of P-gp Inhibition.J Med Chem. 2023 Oct 26;66(20):14080-14094. doi: 10.1021/acs.jmedchem.3c01120. Epub 2023 Aug 24. J Med Chem. 2023. PMID: 37616241 Free PMC article.
References
-
- Akiyama S, Fojo A, Hanover JA, Pastan I, Gottesman MM. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somat. Cell Mol. Genet. 1985;11:117–126. - PubMed
-
- al-Shawi MK, Senior AE. Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein. J. Biol. Chem. 1993;268:4197–4206. - PubMed
-
- Aleman C, Annereau JP, Liang XJ, Cardarelli CO, Taylor B, Yin JJ, Aszalos A, Gottesman MM. P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential. Cancer Res. 2003;63:3084–3091. - PubMed
-
- Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol. 1999;39:361–398. - PubMed
-
- Barattin R, Perrotton T, Trompier D, Lorendeau D, Pietro AD, d'Hardemare Adu M, Baubichon-Cortay H. Iodination of verapamil for a stronger induction of death, through GSH efflux, of cancer cells overexpressing MRP1. Bioorg. Med. Chem. 2010;18:6265–6274. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous