doi: 10.1016/j.bmc.2012.05.062.
Epub 2012 Jun 4.
Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action
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- PMID: 22743086
- DOI: 10.1016/j.bmc.2012.05.062
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Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action
Bioorg Med Chem.
.
Abstract
A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.
Copyright © 2012 Elsevier Ltd. All rights reserved.
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