Epstein-Barr virus infection and posttransplant lymphoproliferative disorder
- PMID: 23347213
- DOI: 10.1111/ajt.12004
Epstein-Barr virus infection and posttransplant lymphoproliferative disorder
Abstract
Epstein-Barr virus (EBV) is an important pathogen in recipients of solid organ transplants (SOT). Infection with EBV manifests as a spectrum of diseases/malignancies ranging from asymptomatic viremia through infectious mononucleosis to posttransplant lymphoproliferative disorder (PTLD). EBV disease and its associated PTLD is more frequently seen when primary EBV infection occurs after transplant, a common scenario in pediatric SOT recipients. Intensity of immunosuppressive therapies also influences the risk for PTLD. The use of EBV viral load monitoring facilitates the diagnosis and management of EBV/PTLD as well as being used to inform preemptive therapy with reduction of immunosuppression, the most effective intervention for prevention of and treatment for PTLD. Other therapies, including the rituximab (anti-CD20 monoclonal antibody) and traditional chemotherapy, are also useful in the treatment of established PTLD. The future development of standards for management based on EBV viral load and routine monitoring of EBV-specific CTL responses promise further improvement in outcomes with EBV and PTLD.
© Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons.
Similar articles
-
The IPTA Nashville Consensus Conference on Post-Transplant lymphoproliferative disorders after solid organ transplantation in children: III - Consensus guidelines for Epstein-Barr virus load and other biomarker monitoring.Pediatr Transplant. 2024 Feb;28(1):e14471. doi: 10.1111/petr.14471. Epub 2023 Jun 9. Pediatr Transplant. 2024. PMID: 37294621 Review.
-
Post-transplant lymphoproliferative disorders, Epstein-Barr virus infection, and disease in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.Clin Transplant. 2019 Sep;33(9):e13652. doi: 10.1111/ctr.13652. Epub 2019 Jul 23. Clin Transplant. 2019. PMID: 31230381
-
Roles of Epstein-Barr virus viral load monitoring in the prediction of posttransplant lymphoproliferative disorder in pediatric liver transplantation.J Formos Med Assoc. 2019 Sep;118(9):1362-1368. doi: 10.1016/j.jfma.2018.12.007. Epub 2019 Jan 3. J Formos Med Assoc. 2019. PMID: 30612881
-
The Changing Epidemiology of Posttransplant Lymphoproliferative Disorder in Adult Solid Organ Transplant Recipients Over 30 Years: A Single-center Experience.Transplantation. 2018 Sep;102(9):1553-1562. doi: 10.1097/TP.0000000000002146. Transplantation. 2018. PMID: 29485513
-
Epstein-Barr virus-related post-transplant lymphoproliferative disorder in solid organ transplant recipients.Clin Microbiol Infect. 2014 Sep;20 Suppl 7:109-18. doi: 10.1111/1469-0691.12534. Clin Microbiol Infect. 2014. PMID: 24475976 Review.
Cited by
-
Single-Center Outcomes of Epstein-Barr Virus DNAemia in Adult Solid Organ Transplant Recipients.J Transplant. 2024 Jan 18;2024:5598324. doi: 10.1155/2024/5598324. eCollection 2024. J Transplant. 2024. PMID: 38283325 Free PMC article.
-
Case Report: Non-negligible Epstein-Barr virus-associated posttransplant lymphoproliferative disorders in a lung transplant recipient.Front Immunol. 2023 Sep 15;14:1244534. doi: 10.3389/fimmu.2023.1244534. eCollection 2023. Front Immunol. 2023. PMID: 37781359 Free PMC article.
-
Prediction of herpes virus infections after solid organ transplantation: a prospective study of immune function.Front Immunol. 2023 Jul 3;14:1183703. doi: 10.3389/fimmu.2023.1183703. eCollection 2023. Front Immunol. 2023. PMID: 37465673 Free PMC article.
-
Important Considerations in the Diagnosis and Management of Post-transplant Lymphoproliferative Disorder.Curr Oncol Rep. 2023 Aug;25(8):883-895. doi: 10.1007/s11912-023-01418-0. Epub 2023 May 10. Curr Oncol Rep. 2023. PMID: 37162742 Review.
-
Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors.J Clin Invest. 2023 Jun 15;133(12):e163548. doi: 10.1172/JCI163548. J Clin Invest. 2023. PMID: 37159273 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical